{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:58:00Z","timestamp":1757703480064},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T00:00:00Z","timestamp":1091664000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p> <jats:italic>We report the case of a 36\u2010year\u2010old man with calcified bicuspid aorta. Aortic disease was diagnosed after retinal embolism, which caused loss of vision affecting the left eye. Doppler examination did not identify carotid stenosis. Transthoracic echocardiography showed thickness and calcification of two leaflets, moderate aortic regurgitation, high normal left ventricular diastolic dimensions, and high normal interventricular septum thickness. Parasternal long\u2010axis view in the systolic frame showed dilated left ventricular outflow tract, dilated ascending aorta, and calcification and thickening of aortic leaflets, causing an echo\u2010lucent area, in the diastolic frame. It also showed the eccentric position of the closed valve leaflets, short axis in the diastolic frame, and the absence of the typical \u201cY\u201d letter sign, tracked by the three leaflets (septal, right coronary, and left coronary) in the normal tricuspid aortic valve. On long\u2010axis parasternal acquisition, we note high normal interventricular septum thickness and high normal diastolic diameter. Color Doppler analysis from the apical five\u2010chamber view showed aortic regurgitation; regurgitant jet area was about 44% of the outflow tract, so aortic regurgitation was classified as moderate. Pulsed Doppler showed a high normal value of peak aortic velocity. Transesophageal echocardiography was performed, but no further findings were identified. We think that the likely retinal embolism sources were the aortic calcified leaflets, even if the aortic valve was not stenotic and with no signs of endocarditis. However, because we cannot exclude other potential causes, we put the patient on anticoagulant therapy. Furthermore, aortic valve replacement was not advised.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.0742-2822.2004.02166.x","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T10:41:01Z","timestamp":1091702461000},"page":"541-544","source":"Crossref","is-referenced-by-count":1,"title":["Retinal Embolization of Bicuspid Aortic Valve Calcification"],"prefix":"10.1111","volume":"21","author":[{"given":"Pasquale","family":"Palmiero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Maiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin C.","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00641-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/euje.2001.0110"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200206000-00002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047689"},{"issue":"12","key":"e_1_2_5_6_2","first-page":"735","article-title":"A retinal embolism subsequent to atheromatous thromboembolism in aortic arch","volume":"76","author":"Barbon Garcia JJ","year":"2001","journal-title":"Arch Soc Esp Ophthalmol"},{"issue":"21","key":"e_1_2_5_7_2","first-page":"945","article-title":"Sudden left\u2010sided vision lass. Occlusion of the left central retinal artery","volume":"90","author":"Stebler J","year":"2001","journal-title":"Schweiz Rundsch Med Prax"},{"issue":"8","key":"e_1_2_5_8_2","first-page":"898","article-title":"Atrial myxoma presenting as isolated unilateral blindness: A case report and review of the literature","volume":"17","author":"Salehian O","year":"2001","journal-title":"Can J Cardiol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.43.193"},{"issue":"4","key":"e_1_2_5_10_2","first-page":"262","article-title":"Unilateral central retinal artery occlusion following intravenous streptokinase","volume":"47","author":"Potdar NA","year":"2001","journal-title":"J Postgrad Med"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0742-2822.2004.02166.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0742-2822.2004.02166.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:37:14Z","timestamp":1697207834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0742-2822.2004.02166.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1111\/j.0742-2822.2004.02166.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0742-2822.2004.02166.x","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}