{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:14:59Z","timestamp":1761707699250},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BSA2001\u20103648"],"award-info":[{"award-number":["BSA2001\u20103648"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>The direct examination of the effects that fish oil diets (composed of long\u2010chain <jats:italic>n\u2010<\/jats:italic>3 polyunsaturated fatty acids) exert on immune system function indicates a reduction of host natural resistance to infectious diseases mainly because of a suppression of immune function generated by the fatty acids contained in this diet. Here, we evaluated the concentration of IL\u201012, IL\u20104, prostaglandin E<jats:sub>2<\/jats:sub> and leukotriene B<jats:sub>4<\/jats:sub> in the serum from BALB\/c mice receiving four different diets. Each group was fed a diet that differed only in the source of fat: a low\u2010fat diet (2.5% by weight), an olive oil diet (20% by weight), a fish oil diet (20% by weight) or a hydrogenated coconut oil diet (20% by weight). Mice were fed for 4 weeks and then infected with the intracellular pathogen <jats:italic>Listeria monocytogenes<\/jats:italic>. An initial reduction in the Th1\u2010type response as a result of a decrease in IL\u201012p70 secretion, an inefficient action of IL\u20104 (Th2\u2010type response) and no modification of pro\u2010inflammatory lipid\u2010mediator production could be, at least in part, the key events responsible for the inadequate elimination of <jats:italic>L. monocytogenes<\/jats:italic> from the spleens of mice fed a fish oil diet. Furthermore, our results suggest that the type of dietary lipids may affect the circulating concentration of IL\u201012p70 and IL\u20104, leading to a modulation in the protective cellular immune response to <jats:italic>L. monocytogenes<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/j.0818-9641.2004.01262.x","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T05:28:20Z","timestamp":1091165300000},"page":"370-376","source":"Crossref","is-referenced-by-count":22,"title":["Changes in the immune functions and susceptibility to <i>Listeria monocytogenes<\/i> infection in mice fed dietary lipids"],"prefix":"10.1111","volume":"82","author":[{"given":"Mar\u00eda A","family":"Puertollano","sequence":"first","affiliation":[{"name":"Unit of Microbiology, Department of Health Sciences, Faculty of Experimental Sciences, University of Ja\u00e9n  Ja\u00e9n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Puertollano","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Ruiz\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Jim\u00e9nez\u2010Valera","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel A","family":"De Pablo","sequence":"additional","affiliation":[{"name":"Unit of Microbiology, Department of Health Sciences, Faculty of Experimental Sciences, University of Ja\u00e9n  Ja\u00e9n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"\u00c1lvarez De Cienfuegos","sequence":"additional","affiliation":[{"name":"Unit of Microbiology, Department of Health Sciences, Faculty of Experimental Sciences, University of Ja\u00e9n  Ja\u00e9n"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01264-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00875.x"},{"key":"e_1_2_7_4_1","first-page":"945","article-title":"Biological and clinical significance of lipids as modulators of immune system functions","volume":"9","author":"Pablo MA","year":"2002","journal-title":"Clin. 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