{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:36:15Z","timestamp":1788870975645,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T00:00:00Z","timestamp":1096329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>\n                    P\u2010glycoprotein (P\u2010gp), an ATP\u2010dependent membrane pump encoded by\n                    <jats:italic>mdr<\/jats:italic>\n                    , plays, in addition to its ability to efflux toxins, a role in the resistance to pathogens. We employed\n                    <jats:italic>mdr1a<\/jats:italic>\n                    gene knock out (\n                    <jats:italic>mdr1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2013\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    ) mice and ectromelia virus (EV) to elucidate the role of P\u2010gp in resistance to EV.\n                    <jats:italic>Mdr1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2013\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice are more susceptible to EV infection than wild type (wt) mice, showing increased mortality and morbidity. Unexpectedly, virus titres in liver, and\n                    <jats:italic>in vitro<\/jats:italic>\n                    in macrophages and splenocytes were significantly lower in the more susceptible\n                    <jats:italic>mdr1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2013\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice than wt littermates. Analysis of immunological mechanisms known to influence resistance to EV infection, such as NK and cytotoxic T cell responses, EV specific antibody and cytokine levels did not reveal significant differences between the two strains of mice. Only dendritic cells from\n                    <jats:italic>mdr1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2013\/\u2013<\/jats:italic>\n                    <\/jats:sup>\n                    mice showed impaired migration to the draining lymph nodes compared to wt mice. Our data show that P\u2010gp plays an important role in EV infection by as yet undefined mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/j.0818-9641.2004.01274.x","type":"journal-article","created":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T06:00:20Z","timestamp":1097128820000},"page":"462-470","source":"Crossref","is-referenced-by-count":6,"title":["The multidrug resistance gene\n                    <i>mdr1a<\/i>\n                    influences resistance to ectromelia virus infection by mechanisms other than conventional immunity"],"prefix":"10.1111","volume":"82","author":[{"given":"Dongmei","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University  Canberra ACT 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Regner","sequence":"additional","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University  Canberra ACT 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne  Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Ruby","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne  Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Cancer Immunology Division, The Peter MacCallum Cancer Institute  East Melbourne Victoria 3002 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"M\u00fcllbacher","sequence":"additional","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University  Canberra ACT 2601 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.62.070193.002125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.9.2451.2451"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.3004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.2.337"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.4.1652"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4538"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.7.2770"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90380-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81370-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119799"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90212-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.4049\/jimmunol.163.5.2621","article-title":"mdr1a\u2010encoded P\u2010glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice","volume":"163","author":"Eisenbraun MD","year":"1999","journal-title":"J. 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