{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:09:53Z","timestamp":1699992593768},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T00:00:00Z","timestamp":1082937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Microbiology and Immunology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Background\/Aim:\u2002<\/jats:bold> Human Herpes Virus\u20108 (HHV\u20108) is a recently identified virus etiologically associated with Kaposi's sarcoma. Studies regarding its presence in the oral cavity have given variable results. This study attempted to determine the oral presence of HHV\u20108 in an area where classic Kaposi's sarcoma is primarily found such as Greece.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three groups of patients were studied: 10 immunocompromised with hematologic malignancies, 10 immunocompromised with HIV infection and 20 immunocompetent as controls. Whole unstimulated saliva and scrapes from the lingual and the buccal mucosa were collected and polymerase chain reaction was applied to amplify HHV\u20108 DNA.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> None of the patients in any group had oral lesions. In the control group, all samples tested negative (0\/60). HHV\u20108 DNA was detected in 5\/30 (17%) of all samples from HIV\u2010positive patients (the mean value of their CD4<jats:sup>+<\/jats:sup> T\u2010lymphocytes being 385\/mm<jats:sup>3<\/jats:sup>) and in 13\/30 (43%) of all samples from oncologic patients (mean CD4<jats:sup>+<\/jats:sup> T\u2010lymphocytes 51\/mm<jats:sup>3<\/jats:sup>). HHV\u20108 DNA was found in 10% of saliva samples and 40% of lingual and buccal scrapes both of HIV\u2010infected and of oncologic patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> HHV\u20108 is present in the saliva and the non\u2010lesional oral mucosa (not simultaneously) of patients with impaired immunity, with or without HIV co\u2010infection. The oral epithelium seems to represent an independent location of viral residency and may be of viral replication; the clinical implications need further clarification.<\/jats:p>","DOI":"10.1111\/j.0902-0055.2002.00131.x","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T10:29:55Z","timestamp":1082975395000},"page":"201-204","source":"Crossref","is-referenced-by-count":21,"title":["Presence of human herpes virus\u20108 in saliva and non\u2010lesional oral mucosa in HIV\u2010infected and oncologic immunocompromised 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