{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:35:35Z","timestamp":1792852535839,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T00:00:00Z","timestamp":1082937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Microbiology and Immunology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Individuals with periodontitis have been reported to have a significantly increased risk of developing coronary heart disease. Several studies have demonstrated that the immune response to heat shock protein 60 (HSP60) may be involved in the pathogenesis of both atherosclerosis and chronic periodontitis. To investigate this possible link between these diseases, cellular and humoral immune responses to HSP60 in atherosclerosis patients were compared with those in periodontitis patients and healthy subjects using human and <jats:italic>Porphyromonas gingivalis<\/jats:italic> HSP60 (GroEL) as antigens. Antibody levels to both human and <jats:italic>P.\u2003gingivalis<\/jats:italic> HSP60s were the highest in atherosclerosis patients, followed by periodontitis patients and healthy subjects. Clonal analysis of the T cells clearly demonstrated the presence of not only human HSP60\u2010 but also <jats:italic>P.\u2003gingivalis<\/jats:italic> GroEL\u2010reactive T\u2010cell populations in the peripheral circulation of atherosclerosis patients. Furthermore, these HSP60\u2010reactive T cells seemed to be present in atherosclerotic lesions in some patients. These results suggest that T\u2010cell clones with the same specificity may be involved in the pathogenesis of the different diseases.<\/jats:p>","DOI":"10.1111\/j.0902-0055.2004.00134.x","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T10:29:55Z","timestamp":1082975395000},"page":"160-167","source":"Crossref","is-referenced-by-count":54,"title":["T\u2010cell clonality to <i>Porphyromonas gingivalis<\/i> and human heat shock protein 60s in patients with atherosclerosis and periodontitis"],"prefix":"10.1111","volume":"19","author":[{"given":"K.","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tabeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390160062027"},{"key":"e_1_2_6_3_2","first-page":"A2\u2013A11","article-title":"The Munster Heart Study (PROCAM): results of follow\u2010up at 8\u2003years","volume":"19","author":"Assmann G","year":"1998","journal-title":"Eur Heart J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70293-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.7.730"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2144"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8941"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100511"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.e20"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/iai.65.2.699-707.1997","article-title":"Cytokine and adhesion molecule expression in human monocytes and endothelial cells stimulated with bacterial heat shock proteins","volume":"65","author":"Gardiero MC","year":"1997","journal-title":"Infect Immun"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb13199.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(94)90265-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170511.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1991.tb00824.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5310"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.13"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb06879.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1560"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.5.437"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1995.tb00136.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00129-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.1.10"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118320"},{"key":"e_1_2_6_24_2","first-page":"654","article-title":"Polyclonal origin of T lymphocytes in human atherosclerotic plaques","volume":"65","author":"Stemme S","year":"1991","journal-title":"Lab Invest"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.7.1210"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01216.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01723.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07117.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.12.1763"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2492-2501.2002"}],"container-title":["Oral Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0902-0055.2004.00134.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0902-0055.2004.00134.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:35:57Z","timestamp":1696952157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0902-0055.2004.00134.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,26]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.0902-0055.2004.00134.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0902-0055.2004.00134.x","archive":["Portico"],"relation":{},"ISSN":["0902-0055","1399-302X"],"issn-type":[{"value":"0902-0055","type":"print"},{"value":"1399-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,26]]}}}