{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:38:36Z","timestamp":1778855916944,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,3]],"date-time":"2004-02-03T00:00:00Z","timestamp":1075766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p><jats:bold>Objective<\/jats:bold> :\u2002To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D\u2010dimer level and to determine the effect of low\u2010dose warfarin on D\u2010dimer level during vaso\u2010occlusive crisis.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002Plasma D\u2010dimer level was measured in 65 blood samples of 37 adult patients with SCD who were hospitalized for vaso\u2010occlusive painful crisis. D\u2010dimer level of patients who were on low\u2010dose warfarin was compared with those patients who were not on any anticoagulation treatment. Analysis of variance (<jats:sc>anova<\/jats:sc>) was carried out to determine factors significantly associated with low D\u2010dimer level in patients with SCD. The following factors were included in the <jats:sc>anova<\/jats:sc> model; warfarin, homozygous hemoglobin S, history of blood transfusion in past 3\u2003months, hydroxyurea, hemoglobin S%, hemoglobin F%, white blood cell counts, hemoglobin level, platelet count, and plasma fibrinogen level.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Overall median D\u2010dimer level in 65 samples was 2.7\u2003<jats:italic>\u03bc<\/jats:italic>g fibrinogen equivalent units (FEU)\/mL (0.34\u20134). Patients who were on low\u2010dose warfarin had a median D\u2010dimer level of 0.81\u2003<jats:italic>\u03bc<\/jats:italic>g FEU\/mL (0.34\u20131.8) compared with 3.1\u2003<jats:italic>\u03bc<\/jats:italic>g FEU\/mL (0.94\u20134) in those patients who were not on anticoagulation treatment. Using <jats:sc>anova<\/jats:sc> to model D\u2010dimer levels, only warfarin was significantly correlated with low D\u2010dimer levels after controlling for other variables.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Patients with SCD during vaso\u2010occulsive painful crisis have an elevated D\u2010dimer level. Low\u2010dose anticoagulation treatment is associated with a significant reduction in the D\u2010dimer levels.<\/jats:p>","DOI":"10.1111\/j.0902-4441.2003.00209.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T20:45:29Z","timestamp":1103748329000},"page":"213-216","source":"Crossref","is-referenced-by-count":18,"title":["Effect of low\u2010dose warfarin on D\u2010dimer levels during sickle cell vaso\u2010occlusive crisis: a brief report"],"prefix":"10.1111","volume":"72","author":[{"given":"Shahid","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita K.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzma","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina P.","family":"Sison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia K.","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip V.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda A.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,3]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Sickle Cell Anemia: Basic Principles and Clinical Practice","author":"Embury SH","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.7.1405.1405"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/15513810109168816"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2001.115450"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3228"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb02989.x"},{"key":"e_1_2_6_8_2","first-page":"169","article-title":"Enhanced thrombin generation in children with sickle cell disease","volume":"71","author":"Peter M","year":"1994","journal-title":"Thrombosis and Hemostasis"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1182\/blood.V68.1.317.317","article-title":"Fragmant D\u2010dimer levels: an objective marker of vaso\u2010occlusive crisis and other complications of sickle cell disease","volume":"68","author":"Devine DV","year":"1986","journal-title":"Blood"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05607.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1175"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/ajcp\/85.3.360","article-title":"Rapid detection of cross\u2010linked fibrin degradation products in plasma using monoclonal antibody\u2010coated latex particles","volume":"85","author":"Elms MJ","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200009000-00007"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0902-4441.2003.00209.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0902-4441.2003.00209.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0902-4441.2003.00209.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:16:45Z","timestamp":1697051805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0902-4441.2003.00209.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,3]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1111\/j.0902-4441.2003.00209.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0902-4441.2003.00209.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,3]]}}}