{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:15:29Z","timestamp":1791152129281,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T00:00:00Z","timestamp":1135209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The association of Epstein\u2013Barr virus (EBV) with human immunodeficiency virus\u2010negative T\u2010cell lymphoma was examined in 68 patients using the polymerase chain reaction (PCR) with DNA obtained from formalin\u2010fixed paraffin\u2010embedded tissues and an <jats:italic>in situ<\/jats:italic> hybridization technique. EBV\u2010encoded RNA (EBER) was detected in 43 of 68 cases (63%) of peripheral T\u2010cell lymphoma: in 100% (11 of 11 cases) of NK\/T\u2010cell lymphomas, 70% (14 of 20 cases) of angioimmunoblastic T\u2010cell lymphomas (AILT) and 49% (18 of 37 cases) of other types of peripheral T\u2010cell lymphoma. A positive band was also detected at high incidence (36 of 65 cases; 55%) in a PCR analysis using primers to detect the Bam HI\u2010W fragment of EBV. In the immunohistochemical analysis using a monoclonal antibody to latent membrane protein 1 (LMP\u20101) of EBV, one of the EBV\u2010encoded latent gene products, LMP\u20101, was found to be expressed in 13 of 64 cases (20%), but EBNA\u20102 was not expressed in all the cases examined (0 of 59 cases; 0%). The 5\u2010yr survival rate was 28% for peripheral T\u2010cell lymphomas overall, 0% for NK\/T\u2010cell lymphomas, 38% for AILTs and 28% for other types of peripheral T\u2010cell lymphoma. The difference in the overall survival rate between NK\/T\u2010cell lymphoma and non\u2010NK\/T\u2010cell lymphoma was significant (<jats:italic>P<\/jats:italic>\u2003=\u20030.0498 by Log\u2010rank test). Among peripheral T\u2010cell lymphoma patients overall, the group severely infected with EBV (EBER\u2010ISH ++) had a lower 5\u2010yr survival rate (8%) than the group slightly (EBER\u2010ISH +) or not infected (38%; <jats:italic>P<\/jats:italic>\u2003=\u20030.0013).<\/jats:p>","DOI":"10.1111\/j.0902-4441.2005.00575.x","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T16:03:04Z","timestamp":1135267384000},"page":"109-118","source":"Crossref","is-referenced-by-count":16,"title":["Association of Epstein\u2013Barr virus with human immunodeficiency virus\u2010negative peripheral T\u2010cell lymphomas in Japan"],"prefix":"10.1111","volume":"76","author":[{"given":"Yuko","family":"Hirose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshioki","family":"Sawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Wano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Umehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008200307625"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A 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