{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T12:19:59Z","timestamp":1712060399618},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T00:00:00Z","timestamp":1135209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We report the first case of primary sclerosing cholangitis (PSC) complicated with plasma cell dyscrasia (PCD) in which liver transplant resulted in unexpected therapeutic benefit of PCD. A 61\u2010year\u2010old man with 12\u2003yr history of PSC presented with a monoclonal gammopathy of undetermined significance (MGUS) with an IgG level of 3400\u2003mg\/dL. It was stable initially for 3\u2003yr but progressed to features consistent with multiple myeloma (MM): IgG rose to 5290\u2003mg\/dL along with development of terminal stage of liver failure. Liver transplant was performed in desperation. Unexpectedly, MM underwent clinical remission following transplant. At 3 and 14\u2003months following transplant, IgG stayed below 2080\u2003mg\/dL and he was able to return to full\u2010time employment. This case may suggest that chronic antigenic stimulation from cirrhotic liver contributed to MGUS and subsequent transformation to MM. Liver transplant eliminated chronic antigenic stimulation, apparently leading to remission of MM. Since PCD is often associated with other chronic liver diseases, similar benefit may accrue to a range of patients with chronic liver diseases complicating PCD.<\/jats:p>","DOI":"10.1111\/j.0902-4441.2005.00589.x","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T16:03:04Z","timestamp":1135267384000},"page":"167-170","source":"Crossref","is-referenced-by-count":1,"title":["Primary sclerosing cholangitis complicating plasma cell dyscrasia (PCD): remission of PCD following liver transplant"],"prefix":"10.1111","volume":"76","author":[{"given":"Vincenzo","family":"Fontana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon S.","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H.","family":"Horstman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas G.","family":"Tzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.384"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000163937"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240317"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1984.tb00935.x"},{"key":"e_1_2_5_6_2","first-page":"113","article-title":"A case of autoimmune hepatitis associated with multiple myeloma demonstrating smooth muscle antibody in M component","volume":"84","author":"Tsuji H","year":"1987","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1981.tb01618.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931001)72:7<2148::AID-CNCR2820720714>3.0.CO;2-Q"},{"key":"e_1_2_5_9_2","first-page":"300","article-title":"Staging and kinetics of multiple myeloma","volume":"13","author":"Durie BG.","year":"1986","journal-title":"Semin Oncol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11100"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0016"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0902-4441.2005.00589.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0902-4441.2005.00589.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:49:25Z","timestamp":1697006965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0902-4441.2005.00589.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,22]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.0902-4441.2005.00589.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0902-4441.2005.00589.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,22]]}}}