{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:19:03Z","timestamp":1773285543076,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T00:00:00Z","timestamp":1071014400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Recent studies have shown that angiotensin peptides accelerate dermal repair. Histological observation of samples taken at the termination of studies showed that the wounds treated with peptides were more mature and organized by day 25 after full thickness excision in diabetic mice. However, the mechanism by which this acceleration occurs has not been determined. In the experiments described here, the effect of angiotensin peptides [AII, A(1\u20137) and NorLeu<jats:sup>3<\/jats:sup>\u2010A(1\u20137)] on the quality of the healing wound was evaluated histologically. Administration of the peptides accelerated collagen deposition, re\u2010epithelialization and new blood vessel formation. By day 4, the percentage of the wound with collagen increased two\u2010 to six\u2010fold depending upon the peptide. The increase by angiotensin peptides continued throughout the experimental period. On days 4 and 7 (only) after injury, exposure to angiotensin peptides increased the number of blood vessels at the wound site two\u2010 to three\u2010fold. Finally, the percentage of the wound site covered with new epithelium increased after administration of angiotensin peptides. Re\u2010epithelialization was observed as early as day 4 in wounds treated with angiotensin peptides. The increase was greater at later time points [up to 8\u2010fold at day 14 with NorLeu<jats:sup>3<\/jats:sup>\u2010A(1\u20137)]. Fibroblast infiltration and proliferation occurred earlier in wounds treated with angiotensin peptides. Wounds treated with A(1\u20137) and NorLeu<jats:sup>3<\/jats:sup>\u2010A(1\u20137) had an increase in neutrophils and macrophages on day 4 after wounding. Overall, administration of these peptides resulted in a healing site that was more mature, including reorganization of the collagen into a basket\u2010weave appearance. Further, these studies confirm the superiority of NorLeu<jats:sup>3<\/jats:sup>\u2010A(1\u20137) to AII and A(1\u20137) in wound healing evaluated at a microscopic level.<\/jats:p>","DOI":"10.1111\/j.0906-6705.2003.00087.x","type":"journal-article","created":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T20:42:29Z","timestamp":1071088949000},"page":"784-790","source":"Crossref","is-referenced-by-count":40,"title":["Histological evaluation of the effects of angiotensin peptides on wound repair in diabetic mice"],"prefix":"10.1111","volume":"12","author":[{"given":"Kathleen E.","family":"Rodgers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Roda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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