{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:10Z","timestamp":1791216670553,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T00:00:00Z","timestamp":1100736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Type\u20101 cytokine\u2010producing T cells are important in the pathogenesis of psoriasis vulgaris, for which efficient therapy is provided by means of narrow\u2010band ultraviolet\u2010B (NB\u2010UVB). The expression of the type\u20101 cytokine interferon\u2010\u03b3 (IFN\u2010\u03b3) is regulated by interleukin\u201012 (IL\u201012), IL\u201015, IL\u201018 and IL\u201023; however, not much is known about the effect of this therapy on the levels of these cytokines in lesional psoriatic skin <jats:italic>in situ<\/jats:italic>. In this study, we investigated the effects of NB\u2010UVB therapy on the expression of IFN\u2010\u03b3\u2010inducing cytokines. Ten patients with chronic plaque\u2010type psoriasis selected to be treated with NB\u2010UVB therapy were recruited for these experiments and the expression of cytokines IL\u201012, IL\u201015, IL\u201018, IL\u201023 and IFN\u2010\u03b3 in lesional psoriatic skin before, during and after therapy was determined with the help of immunohistochemistry. Double staining was performed in order to determine the cell types expressing these cytokines. The decrease in the psoriasis area and severity index was accompanied by a significant decrease in the expression of IFN\u2010\u03b3, and concomitantly, significant reduction of IFN\u2010\u03b3inducers \u2013 IL\u201012, IL\u201018 and IL\u201023. Thus, we concluded that the decrease of IFN\u2010\u03b3 expression in psoriasis lesions after NB\u2010UVB therapy could be a result of diminished expression of IL\u201012, IL\u201018 and IL\u201023 in lesional skin. Therapies targeting these three cytokines should, therefore, be considered in the treatment of psoriasis.<\/jats:p>","DOI":"10.1111\/j.0906-6705.2004.00246.x","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T13:34:54Z","timestamp":1100784894000},"page":"764-772","source":"Crossref","is-referenced-by-count":96,"title":["Clinical improvement in chronic plaque\u2010type psoriasis lesions after narrow\u2010band UVB therapy is accompanied by a decrease in the expression of IFN\u2010\u03b3 inducers \u2013 IL\u201012, IL\u201018 and IL\u201023"],"prefix":"10.1111","volume":"13","author":[{"given":"G.","family":"Piskin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Tursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M. 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