{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:48Z","timestamp":1791252888794,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,27]],"date-time":"2004-02-27T00:00:00Z","timestamp":1077840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The vanilloid receptor subtype 1 (VR1)\/(TRPV1), binding capsaicin, is a non\u2010selective cation channel that recently has been shown in human keratinocytes <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. However, a description of VR1 localization in other cutaneous compartments in particular cutaneous nerve fibers is still lacking. We therefore investigated VR1 immunoreactivity as well as mRNA and protein expression in a series (<jats:italic>n<\/jats:italic>\u2003=\u200326) of normal (<jats:italic>n<\/jats:italic>\u2003=\u20037), diseased (<jats:italic>n<\/jats:italic>\u2003=\u200313) [prurigo nodularis (PN) (<jats:italic>n<\/jats:italic>\u2003=\u200310), generalized pruritus (<jats:italic>n<\/jats:italic>\u2003=\u20031), and mastocytosis (<jats:italic>n<\/jats:italic>\u2003=\u20032)], and capsaicin\u2010treated human skin (<jats:italic>n<\/jats:italic>\u2003=\u20036). VR1 immunoreactivity could be observed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands. Upon reverse transcriptase\u2010polymerase chain reaction and Western blot analysis, VR1 was detected in mast cells and keratinocytes from human skin. In pruritic skin of PN, VR1 expression was highly increased in epidermal keratinocytes and nerve fibers, which was normalized after capsaicin application. During capsaicin therapy, a reduction of neuropeptides (substance P, calcitonin gene\u2010related peptide) was observed. After cessation of capsaicin therapy, neuropeptides re\u2010accumulated in skin nerves. In conclusion, VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.<\/jats:p>","DOI":"10.1111\/j.0906-6705.2004.0178.x","type":"journal-article","created":{"date-parts":[[2004,2,27]],"date-time":"2004-02-27T08:31:48Z","timestamp":1077870708000},"page":"129-139","source":"Crossref","is-referenced-by-count":344,"title":["Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage 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