{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:26Z","timestamp":1789977086431,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Genetic factors that predispose individuals to Beh\u00e7et's disease (BD) are considered to play important roles in the development of the disease. The pro\u2010inflammatory cytokine interleukin\u20101 (IL\u20101) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL\u20101\u03b1, IL\u20101\u03b2, and IL\u20101 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL\u20101\u03b1\u2212889, IL\u20101\u03b2\u2212511, and +3953 (nt5887) single\u2010nucleotide polymorphisms besides IL\u20101 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL\u20101\u03b2+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR\u2003=\u20031.74, <jats:italic>P<\/jats:italic>\u2003=\u20030.024, and 40.3 vs. 19.6%, OR\u2003=\u20032.76, <jats:italic>P<\/jats:italic>\u2003=\u20030.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL\u20101\u03b1\u2212889, IL\u20101\u03b2\u2212511, and IL\u20101 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL\u20101\u03b2+3953 T allele and TT genotype.<\/jats:p>","DOI":"10.1111\/j.0906-6705.2005.00253.x","type":"journal-article","created":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T16:58:34Z","timestamp":1106845114000},"page":"124-129","source":"Crossref","is-referenced-by-count":50,"title":["Specific interleukin\u20101 gene polymorphisms in Turkish patients with Beh\u00e7et's 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