{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:08:08Z","timestamp":1790215688871,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Clinical observations of non\u2010melanoma skin cancer in immunocompromised patients, such as organ transplant recipients, suggest co\u2010operative effects of human papillomavirus (HPV) and ultraviolet (UV) radiation. The aim of the present study is to evaluate UV sensitivity and DNA damage formation according to antioxidant status in HPV16\u2010infected keratinocytes. We used SKv cell lines, infected with HPV16 and well characterized for their proliferative and tumorigenic capacities. We showed that SKv cell lines presented various E6* (a truncated form of E6) RNA levels. We demonstrated that the higher oncoprotein RNA expression level was associated with a higher resistance to solar\u2010simulated radiation, more specifically to UVB radiation and to hydrogen peroxide. Moreover, this high resistance was associated with a low oxidative DNA damage formation after UV radiation and was related to high glutathione content and glutathione peroxidase activities. Therefore, the results of our study suggest that E6* levels could modulate the glutathione\/glutathione peroxidase pathway providing a mechanism to protect HPV\u2010infected keratinocytes against an environmental oxidative stress, such as UV radiation.<\/jats:p>","DOI":"10.1111\/j.0906-6705.2005.00296.x","type":"journal-article","created":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T08:06:10Z","timestamp":1115712370000},"page":"401-410","source":"Crossref","is-referenced-by-count":18,"title":["E6* oncoprotein expression of human papillomavirus type\u201016 determines different ultraviolet sensitivity related to glutathione and glutathione peroxidase antioxidant defence"],"prefix":"10.1111","volume":"14","author":[{"given":"St\u00e9phane","family":"Mouret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Sauvaigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Peinnequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Favier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Beani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Leccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"F55","article-title":"Papillomavirus infections \u2013 a major cause of human cancers","volume":"1288","author":"Zur Hausen H","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_6_3_2","first-page":"1074","article-title":"Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis. 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