{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:57:26Z","timestamp":1793829446751,"version":"4.6.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T00:00:00Z","timestamp":1121212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> To determine any correlation between the stratum corneum barrier function and the phenotypic severity of congenital ichthyosis, we studied stratum corneum hydration, flexibility, thickness and transepidermal water loss (TEWL) in patients with congenital ichthyosis. Seven patients with congenital ichthyosis aged 2\u201346 years and age\u2010matched controls were included in the present study. We divided seven patients into two groups; patients with non\u2010bullous type (non\u2010bullous congenital ichthyosiform erythroderma patients) and patients with the bullous type of congenital ichthyosis (bullous congenital ichthyosiform erythroderma and ichthyosis bullosa of Siemens). Stratum corneum hydration, thickness and flexibility were measured using a Corneometer ASA\u2010M2. The stratum corneum thickness was also examined using a skin biopsy technique. TEWL was measured using Evaporimeter AS\u2010TW1. The clinical severity of ichthyosis phenotype was evaluated using a visual analogue scale (VAS). Stratum corneum hydration and flexibility were significantly reduced in both congenital ichthyosis patient groups. Stratum corneum thickness was significantly increased in both groups. In the patient group with non\u2010bullous congenital ichthyosis, significant negative correlations were confirmed between the VAS score and stratum corneum hydration and between the VAS score and flexibility. A significant, positive correlation was also observed between the VAS score and stratum corneum thickness. There was a positive correlation between the VAS score and TEWL on both the extensor and flexor sides of the forearm and back. We conclude that stratum corneum hydration, flexibility and thickness measured by the corneometer, and TEWL on the arm may be a useful indicator of the severity of ichthyosis phenotype. \u2028<\/jats:p>","DOI":"10.1111\/j.0906-6705.2005.00341.x","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T09:35:10Z","timestamp":1133948110000},"page":"619-624","source":"Crossref","is-referenced-by-count":35,"title":["Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis"],"prefix":"10.1111","volume":"14","author":[{"given":"Yuki","family":"Tomita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/archderm.1985.01660040061013","article-title":"Heterogeneity in autosomal recessive ichthyosis","volume":"121","author":"Williams M L","year":"1985","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_3_2","first-page":"1483","volume-title":"Textbook of Dermatology","author":"Griffiths W A D","year":"1998"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00488.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00021.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00728.x"},{"key":"e_1_2_6_7_2","article-title":"Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing","author":"Akiyama M","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03200.x"},{"key":"e_1_2_6_9_2","first-page":"34","article-title":"Measurement and analysis of skin electrical impedance","volume":"185","author":"Yamamoto Y","year":"1994","journal-title":"Acta Derm Venereol Suppl"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01452.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12323752"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.052"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.110308.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01471.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00482.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372011"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0906-6705.2005.00341.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0906-6705.2005.00341.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:02:34Z","timestamp":1697364154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0906-6705.2005.00341.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,13]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.0906-6705.2005.00341.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0906-6705.2005.00341.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,13]]}}}