{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:46:48Z","timestamp":1773920808858,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:00:00Z","timestamp":1160006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Objective: <\/jats:bold> In the present study, we evaluated the anti\u2010inflammatory activity of <jats:italic>Poria cocos<\/jats:italic> (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> The anti\u2010irritative effect of PoCo was evaluated with a visual score and quantified by non\u2010invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations of PoCo in base cream DAC (amphiphilic emollient; German pharmacopoeia) were tested in a 4\u2010day repetitive irritation test using SLS.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> A statistically significant anti\u2010inflammatory activity was observed for PoCo by all three methods when applied in parallel to the induction period of ICD. Application of PoCo after induction of ICD once a day for 5 days, starting just at the end of 4 days, was without any effect.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> An anti\u2010inflammatory efficacy of PoCo on the elicitation phase of the ICD induced by repeated SLS test could be observed and quantified by three independent, non\u2010invasive biophysical assessment parameters. This effect can be explained by its influence on pro\u2010inflammatory enzymes, namely phospholipase A2.<\/jats:p>","DOI":"10.1111\/j.0909-752x.2006.00168.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:54:50Z","timestamp":1160063690000},"page":"223-227","source":"Crossref","is-referenced-by-count":29,"title":["Assessment of anti\u2010inflammatory activity of <i>Poria cocos<\/i> in sodium lauryl sulphate\u2010induced irritant contact dermatitis"],"prefix":"10.1111","volume":"12","author":[{"given":"S. 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