{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:32:55Z","timestamp":1791268375444,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:00:00Z","timestamp":1160006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background\/purpose: <\/jats:bold> Vitiligo and nevus depigmentosus (ND) present similar hypopigmented macules with significantly different prognoses. Although the distinction between the two diseases is important, differential diagnosis relies on medical history and physical examination, which is far from decisive in some cases. The Mexameter<jats:sup>\u00ae<\/jats:sup> is an objective skin color\u2010measuring device, and has been reported to provide a reproducible and sensitive means of quantifying small skin color differences. In this study, we investigated the usefulness of a Mexameter<jats:sup>\u00ae<\/jats:sup> for discriminating these diseases.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> A selection of 202 hypopigmented skin lesions (182 from vitiligo and 20 from ND) were the objects of this study. Using a Mexameter, MIs were obtained from lesions and symmetrically located control skin. RMIs, ratios of the MIs of lesional skins to control skins, were calculated.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The mean MIs and RMIs were significantly different for vitiligo and ND. The mean RMI of ND lesions was 74\u00b113, which was significantly higher than that of vitiligo lesions (50\u00b124). No ND lesion had an RMI of &lt;50%.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> This study shows that the Mexameter<jats:sup>\u00ae<\/jats:sup>, an objective pigment\u2010measuring device, can be used to achieve a more accurate diagnosis of hypopigmentary disorders, and that the relative melanin index (RMI), which represents the relative pigment levels, might be a more effective parameter than the melanin index (MI) itself for comparing pigmentation differences.<\/jats:p>","DOI":"10.1111\/j.0909-752x.2006.00187.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:54:50Z","timestamp":1160063690000},"page":"298-302","source":"Crossref","is-referenced-by-count":40,"title":["Application of a pigment measuring device \u2013 Mexameter<sup>\u00ae<\/sup>\u2013 for the differential diagnosis of vitiligo and nevus depigmentosus"],"prefix":"10.1111","volume":"12","author":[{"given":"Eun Sang","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Im","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hun","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Chan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"836","volume-title":"Dermatology in general medicine","author":"Ortonne JP","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000254235"},{"key":"e_1_2_6_4_2","first-page":"21","article-title":"Nevus depigmentosus","volume":"40","author":"Lee HS","year":"1999","journal-title":"clinical features and histopathologic characteristics in 67 patients"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.1993.32.4.269"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002660010109"},{"key":"e_1_2_6_7_2","first-page":"230","article-title":"Skin color measurements","volume":"6","author":"Clarys P","year":"2000","journal-title":"comparison between threee instruments: the Chromameter\u00ae, the DermaSpectrometer\u00ae and the Mexameter\u00ae"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb14149.x"},{"key":"e_1_2_6_9_2","first-page":"612","article-title":"Clinical features of nevus depigmentosus in 104 patients","volume":"38","author":"Yu HJ","year":"2000","journal-title":"Korean J Dermatol"},{"key":"e_1_2_6_10_2","first-page":"429","article-title":"The study on the clinical characteristics of childhood vitiligo","volume":"41","author":"Choe HC","year":"2003","journal-title":"Korean J Dermatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506603"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH659>3.0.CO;2-D"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.70305.x"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0909-752X.2006.00187.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0909-752X.2006.00187.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:27:41Z","timestamp":1697279261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0909-752X.2006.00187.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,5]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.0909-752X.2006.00187.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0909-752x.2006.00187.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,5]]}}}