{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:10:37Z","timestamp":1761675037618},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,31]],"date-time":"2004-03-31T00:00:00Z","timestamp":1080691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Osteoclasts in osteopetrotic (<jats:italic>op\/op<\/jats:italic>) mice are substantially reduced by the absence of functional activities of macrophage colony\u2010stimulating factor (M\u2010CSF). However, it is known that osteoclasts appear in <jats:italic>op\/op<\/jats:italic> skeletal bones with aging, although the molecular mechanism for this is unknown. In order to investigate osteoclastic recruitment in the jaw bones of <jats:italic>op\/op<\/jats:italic> mice, osteoclastic distribution was analysed for 2\u2003yr after birth by histochemistry for tartrate\u2010resistant acid phosphatase activity and immunohistochemistry for cathepsin K. Osteoclasts in <jats:italic>op\/op<\/jats:italic> mandibular bones decreased rapidly in number after birth and disappeared by 3\u2003d, although there was no difference in the osteoclastic distribution between <jats:italic>op\/op<\/jats:italic> and normal littermates at birth. At 2\u2003wk, osteoclasts began to reappear around <jats:italic>op\/op<\/jats:italic> tooth germs, where no apparent connective tissue layer intervened between tooth germs and bone trabeculae. They increased in number and were scattered over the mandible, reaching a maximum at 8\u2003wk, when periodontal ligament\u2010like structures were recognizable around incisor germs. Osteoclasts then again decreased gradually, and after 62\u2003wk few osteoclasts were seen in <jats:italic>op\/op<\/jats:italic> mandibular bones, whose marrow space disappeared. These findings suggest that osteoclasts are recruited in an M\u2010CSF\u2010independent manner in <jats:italic>op\/op<\/jats:italic> mandibles, especially in areas around tooth germs.<\/jats:p>","DOI":"10.1111\/j.0909-8836.2004.00109.x","type":"journal-article","created":{"date-parts":[[2004,3,31]],"date-time":"2004-03-31T09:47:01Z","timestamp":1080726421000},"page":"148-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recruitment of osteoclasts in the mandible of osteopetrotic (<i>op\/op<\/i>) 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