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Axons projecting from the different OE zones and VN subpopulations form synapses within circumscribed regions in the glomerular layer of the olfactory bulb (OB) and accessory olfactory bulb (AOB), respectively. We here show that mature neurons in one defined zone selectively express NADPH:quinone oxidoreductase (NQO1), an enzyme that catalyses reduction of quinones. Immunohistochemistry and <jats:italic>in situ<\/jats:italic> hybridization analyses show non\u2010overlapping expression of NQO1 and the Rb8 neural cell adhesion molecule (RNCAM\/OCAM) in OE and axon terminals within glomeruli of the OB. In addition, NQO1 immunoreactivity reveals selective, zone\u2010specific axon fasciculation in the olfactory nerve. VN subpopulations do not show complementary patterns of RNCAM and NQO1 immunoreactivity, instead both genes are co\u2010expressed in apical VN neurons that project to the rostral AOB. These results indicate that one division of both the accessory and the main olfactory projection maps are composed of sensory neurons that are specialized to reduce environmental and\/or endogenously produced quinones via an NQO1\u2010dependent mechanism. The role of NQO1 in bioactivation of quinoidal drugs also points to a connection between zone\u2010specific NQO1 expression and zone\u2010specific toxicity of certain olfactory toxins.<\/jats:p>","DOI":"10.1111\/j.0953-816x.2004.03331.x","type":"journal-article","created":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T15:53:33Z","timestamp":1083254013000},"page":"2511-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps"],"prefix":"10.1111","volume":"19","author":[{"given":"Fredrik","family":"Gussing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Bohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26083"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00317"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050143"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1523\/JNEUROSCI.16-03-00909.1996","article-title":"Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha i2, and adenylyl cyclase II as major components of a pheromone signaling cascade","volume":"16","author":"Berghard A.","year":"1996","journal-title":"J. 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