{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:13Z","timestamp":1772160433414,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T00:00:00Z","timestamp":1083196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Behavioural effects of psychostimulant and opiate drugs are mediated in part by cAMP pathways operating in the nucleus accumbens. Degradation of cAMP occurs through the action of phosphodiesterases, such as the Type\u2003IV phosphodiesterases (PDE4s) that are found throughout the brain. To examine the potential role of PDE4 in reward\u2010mediated behaviour, we measured the effects of rolipram, a PDE4 selective inhibitor, on cocaine (18\u2003mg\/kg i.p.) and morphine (5\u2003mg\/kg s.c.) conditioned place preference in Swiss Webster mice. Rolipram (0, 0.2 or 1.0\u2003mg\/kg i.p.) given 30\u2003min prior to drug administration dose\u2010dependently reduced conditioning due to both cocaine and morphine. However, rolipram did not affect place preference induced by food, nor did it prevent the expression of a previously established place preference conditioned by cocaine or morphine. In a second experiment, rolipram administered 30\u2003min prior to a single cocaine injection (50\u2003mg\/kg i.p.), did not alter cocaine\u2010induced c\u2010Fos expression in the caudate putamen or nucleus accumbens core. However, rolipram, but not cocaine, induced c\u2010Fos in the nucleus accumbens shell. These results indicate that elevation of cAMP in neurons that express PDE4s may attenuate the rewarding properties of cocaine and morphine, but does not alter the cocaine signalling cascade that induces c\u2010Fos expression. Thus, PDE4\u2010mediated regulation of cAMP levels could underlie the establishment of reward valence to abused drugs.<\/jats:p>","DOI":"10.1111\/j.0953-816x.2004.03357.x","type":"journal-article","created":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T11:53:33Z","timestamp":1083239613000},"page":"2561-2568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Type\u2003IV phosphodiesterase inhibitor rolipram interferes with drug\u2010induced conditioned place preference but not immediate early gene induction in mice"],"prefix":"10.1111","volume":"19","author":[{"given":"Barbara E.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Kantak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100833"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5280"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.15020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172091899"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-002-0533-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2272"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00389-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990503)407:2<287::AID-CNE9>3.0.CO;2-R"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R200029200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244173"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00145-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.5.1684"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118897"},{"key":"e_1_2_6_16_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin K.B.J.","year":"1997"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.17.6912"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00315-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02741385"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021698"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.1998.20.7.485728"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00479-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-09841.2002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(96)00006-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00154-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498258809041693"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90252-D"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.51.5.755"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/41567"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703912"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00164-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14928"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.83.113"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704629"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80110-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/105504901750532094"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00267-6"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.326"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00950-3"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(01)00169-3"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00426-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00218-U"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90295-8"},{"key":"e_1_2_6_44_1","first-page":"900","article-title":"4\u2010(3\u2010Cyclopentyloxy\u20104\u2010methoxyphenyl)\u20102\u2010pyrrolidone (ZK 62711): a potent inhibitor of adenosine cyclic\u20103\u2032,5\u2032\u2010monophosphate phosphodiesterases in homogenates and tissue slices from rat brain","volume":"12","author":"Schwabe U.","year":"1976","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265852"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-05-01848.1998"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-10-06239.1994"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00257-9"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00233-3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1995.tb09881.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199909000-00007"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00165-9"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00060-4"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20894"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(83)90239-3"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01243273"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00063-5"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1291"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00108-1"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01089.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-j0001.2000"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0953-816X.2004.03357.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0953-816X.2004.03357.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:01:46Z","timestamp":1697212906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0953-816X.2004.03357.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,29]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.0953-816X.2004.03357.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0953-816x.2004.03357.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1018911.214484","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,29]]},"assertion":[{"value":"2004-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}