{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:47:07Z","timestamp":1774518427670,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), inappropriately elevated secretion of vasopressin can result in a reduction of antidiuretic efficacy: a phenomenon known as \u2018vasopressin escape\u2019. We compared experimental SIADH with 1\u2010deamino\u20108\u2010<jats:sc>d<\/jats:sc>\u2010arginine vasopressin (dDAVP)\u2010excess rats, where both groups received continuous subcutaneous administration of dDAVP by osmotic minipump but the SIADH rats also received a liquid diet that induced hyponatraemia. The SIADH rats, but not the dDAVP excess rats, showed a marked attenuation of urinary concentrating ability. Vasopressin V<jats:sub>2<\/jats:sub> receptor binding capacity and mRNA expression were similar between the two groups, but the SIADH rats showed a diminished up\u2010regulation of aquaporin\u20102 (AQP\u20102) mRNA and protein expression. These findings indicate the presence of tonicity\u2010response regions in the AQP\u20102 promoter gene, and that either hypervolemia or hypotonicity may attenuate the postreceptor signalling of vasopressin in renal collecting duct cells in SIADH rats.<\/jats:p>","DOI":"10.1111\/j.0953-8194.2004.01177.x","type":"journal-article","created":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T08:24:17Z","timestamp":1082103857000},"page":"293-296","source":"Crossref","is-referenced-by-count":15,"title":["Pathological Role of Aquaporin\u20102 in Impaired Water Excretion and Hyponatremia"],"prefix":"10.1111","volume":"16","author":[{"given":"S.","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kasono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810203191606"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191705"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01647.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90096-4"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1480221"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.4.1665"},{"key":"e_1_2_5_8_2","first-page":"532","volume-title":"The Kidney.","author":"Knepper MA","year":"1995"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/361549a0"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117079"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V86861"},{"key":"e_1_2_5_12_2","first-page":"F183","article-title":"Alteration in water channel AQP\u20102 by removal of vasopressin stimulation in collecting duct cells of dehydrated rats","volume":"272","author":"Saito T","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_5_13_2","first-page":"F926","article-title":"Role of water channel AQP\u2010CD in water channel in SIADH and cirrhotic rats","volume":"269","author":"Fujita N","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119312"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI649"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F502"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.31.020180.001531"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119352"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.1.307"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00965.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1681\/ASN.V10102067","article-title":"Kidney aquaporin\u20102 expression during escape from antidiuresis is not related to plasma or tissue osmolality","volume":"10","author":"Murase T","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00245.2002"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0953-8194.2004.01177.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0953-8194.2004.01177.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:39:33Z","timestamp":1697139573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0953-8194.2004.01177.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.0953-8194.2004.01177.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0953-8194.2004.01177.x","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}