{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:50:20Z","timestamp":1778277020229,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance imaging (MRI) is a revolutionary advance in diagnostic imaging of the hypothalamic\u2010neurohypophyseal system (HNS). The detailed anatomy of the sellar and parasellar region is clearly visible using MRI, because it has no bony artifacts and multidirectional capability. The posterior lobe of the pituitary gland displays a characteristic bright signal on the MR T1\u2010weighted image (T1WI), and is distinctly separated from the anterior lobe. The bright signal is absent in patients with central diabetes insipidus, and is thought to reflect normal vasopressin storage in the posterior lobe. The signal intensity ratio of the posterior lobe to the pons on T1WI is strongly correlated with vasopressin content in the posterior lobe. In addition to the morphological evaluation, MRI provides unique information concerning the function of the HNS. The MRI findings of the HNS (normal condition, central diabetes insipidus, a depleted posterior lobe, an ectopic posterior lobe, and a damming\u2010up phenomenon of the neurosecretory vesicles in the pituitary stalk) are demonstrated in this article.<\/jats:p>","DOI":"10.1111\/j.0953-8194.2004.01183.x","type":"journal-article","created":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T08:24:17Z","timestamp":1082103857000},"page":"297-302","source":"Crossref","is-referenced-by-count":73,"title":["Magnetic Resonance Imaging of the Hypothalamic\u2010Neurohypophyseal System"],"prefix":"10.1111","volume":"16","author":[{"given":"I.","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,16]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.1.8451394"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198703000-00004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198905000-00001"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.207.1.9530302"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198703000-00003"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.2.3659370"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.2805"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.00555.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.1.7997567"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199307000-00024"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200203000-00001"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.2.3659371"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.49.165"},{"key":"e_1_2_9_15_2","first-page":"822","article-title":"Correlation of high signal intensity of the pituitary stalk in macroadenoma and postoperative diabetes insipidus","volume":"23","author":"Saeki N","year":"2002","journal-title":"AJNR"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910901)68:5<1009::AID-CNCR2820680517>3.0.CO;2-R"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0446"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309023291002"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.1.153"},{"key":"e_1_2_9_20_2","first-page":"1280","article-title":"Hyperintense signals of the posterior lobe of the pituitary gland on MR images","volume":"10","author":"Fujisawa I","year":"1989","journal-title":"AJNR"},{"key":"e_1_2_9_21_2","first-page":"693","article-title":"The effect of phospholipid vesicles on the NMR relaxation of water. an explanation for the MR appearance of the neurohypophysis?","volume":"11","author":"Kucharczyk W","year":"1990","journal-title":"AJNR"},{"key":"e_1_2_9_22_2","first-page":"581","article-title":"Hyperintense signal on MR images of the pituitary gland","volume":"12","author":"Fujisawa I","year":"1991","journal-title":"AJNR"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199510000-00001"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199703000-00002"},{"key":"e_1_2_9_25_2","first-page":"167","volume-title":"Oxytocin. Clinical and Laboratory Studies","author":"Forsling ML","year":"1985"},{"key":"e_1_2_9_26_2","first-page":"341","volume-title":"Williams Textbook of Endocrinology","author":"Reeves WB","year":"1998"},{"key":"e_1_2_9_27_2","first-page":"R1121","article-title":"Models of neurohypophyseal homeostasis","volume":"262","author":"Fitzsimmons MD","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_9_28_2","first-page":"111","volume-title":"Pharmacology of the Endocrine System and Related Drugs: the Neurohypophysis","author":"Lederis K","year":"1970"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.5.503"},{"key":"e_1_2_9_30_2","first-page":"1183","volume-title":"Progress in Endocrinology.","author":"Jard S","year":"1988"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9516"},{"key":"e_1_2_9_32_2","first-page":"E217","article-title":"Vasopressin V1 and V2 receptors in diabetes mellitus","volume":"266","author":"Trinder D","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10397"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80190-6"},{"key":"e_1_2_9_35_2","first-page":"1273","article-title":"Use of T1\u2010weighted MR imaging to differentiate between primary polydipsia and central diabetes insipidus","volume":"13","author":"Moses AM","year":"1992","journal-title":"AJNR"},{"key":"e_1_2_9_36_2","first-page":"11","volume-title":"The Neurohypophysis, Proceedings of the 8th Symposium of the Colston Research Society Held in the University of Bristol","author":"Bargmann W","year":"1957"},{"key":"e_1_2_9_37_2","first-page":"439","volume-title":"Disorders of the Pituitary","author":"Tindall GT","year":"1986"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-56-6-704"},{"key":"e_1_2_9_39_2","first-page":"589","volume-title":"Textbook of Endocrinology","author":"Reichlin S","year":"1981"},{"key":"e_1_2_9_40_2","first-page":"664","article-title":"Neurohypophyseal function of an ectopic posterior lobe in patients with growth hormone deficiency","volume":"122","author":"Yamanaka C","year":"1990","journal-title":"Acta Endocrinol (Copenh)"},{"key":"e_1_2_9_41_2","first-page":"69","article-title":"Studies of the hypothalamus and the pituitary gland: with special reference to the effects of transection of the pituitary stalk","volume":"201","author":"Daniel PM","year":"1975","journal-title":"Acta Endocrinol (Suppl Copenh)"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-4-817"},{"key":"e_1_2_9_43_2","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1210\/jcem.84.7.5849","article-title":"Growth hormone deficiency with ectopic neurohypophysis: anatomical variations and relationship between the visibility of the pituitary stalk asserted by magnetic resonance imaging and anterior pituitary function","volume":"84","author":"Chen S","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011936"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.24.139"},{"key":"e_1_2_9_46_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1542\/peds.93.3.409","article-title":"Evidence of a congenital midline brain anomaly in pituitary dwarfs: a magnetic resonance imaging study in 101 patients","volume":"93","author":"Triulzi F","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.00789.x"},{"key":"e_1_2_9_48_2","first-page":"957","article-title":"Breech presentatation and Caesarean section","volume":"26","author":"Iwasaki K","year":"1996","journal-title":"Shusanki Igaku"},{"key":"e_1_2_9_49_2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1242\/jeb.31.3.322","article-title":"Studies on the transport of neurosecretory material in Calliphora erythrocephala by means of ligaturing experiments","volume":"31","author":"Thomsen E","year":"1955","journal-title":"J Exp Biol"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00330504"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0953-8194.2004.01183.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0953-8194.2004.01183.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:39:02Z","timestamp":1697139542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0953-8194.2004.01183.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.0953-8194.2004.01183.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0953-8194.2004.01183.x","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}