{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:46:26Z","timestamp":1761057986972},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T00:00:00Z","timestamp":1084924800000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute pancreatitis (AP) is characterized by initial pancreatic injury resulting from the activation of digestive enzymes and, later, widespread inflammation to distant organs. The aim of this study was to study whether the time\u2010course of inflammatory events during AP induced by bile\u2010pancreatic duct obstruction (BPDO) varies after lowering the acinar enzyme content by L364,718 (0.1\u2003mg\/kg\/day) administration over 7 days before inducing AP. Flow cytometric immunophenotyping was used to analyse the following at different AP stages: distribution of major circulating leucocyte subsets, activation state of circulating neutrophils and monocytes as reflected by CD11b expression and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) production and the contribution of T\u2010cell\u2010derived pro\u2010(TNF\u2010\u03b1) and anti\u2010(IL\u201010) inflammatory mediators. TNF\u2010\u03b1 plasma levels and neutrophil infiltration in pancreas and lung were also measured. At early BPDO times, L364,718 treatment partially inhibited leukocytosis and increase in peripheral blood neutrophils and monocytes as well as TNF\u2010\u03b1 expression by monocytes. However, from 6\u2003h onwards after BPDO, L364,718 treatment was unable to prevent either pancreatic and lung neutrophil infiltration or the release of TNF\u2010\u03b1 from activated monocytes. By its action on circulating lymphocytes, L364,718 treatment enhanced the severity of the inflammatory response induced by BPDO. Peripheral blood lymphocytes were recruited from earlier BPDO times, and 12\u2003h after BPDO, T cells displayed a significantly higher reserve of TNF\u2010\u03b1 able to be released under stimulation but lower functional reserve of interleukin\u201010 (IL\u201010) than observed in untreated rats. It is concluded that lowering the acinar enzyme content through L364,718 treatment prevents earlier systemic immune events in BPDO\u2010induced AP. However, at the point of maximal injury, the inflammatory response became pronounced, largely due to the role played by activated T lymphocytes.<\/jats:p>","DOI":"10.1111\/j.0959-9673.2004.00372.x","type":"journal-article","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T16:07:32Z","timestamp":1084982852000},"page":"75-84","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cholecystokinin blockade alters the systemic immune response in rats with acute pancreatitis"],"prefix":"10.1111","volume":"85","author":[{"given":"Ana Maria","family":"De La Mano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sevillano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Antonio","family":"Manso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel de","family":"Dios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114265"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.838"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830811"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.2011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020603724002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70265-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316507"},{"key":"e_1_2_6_10_1","first-page":"164","article-title":"Pancr\u00e9atite aigu\u00eb: nouvelles donn\u00e9es physiopathologiques","volume":"25","author":"Frossard J.L.","year":"2001","journal-title":"Gastroenterol. 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