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Here, we describe the detailed histopathology of systemic anthrax infection in A\/J mice infected with <jats:italic>Bacillus anthracis<\/jats:italic> Sterne, a strain with reduced virulence for humans. Subcutaneous infection leads to systemic disease with multiple pathologies including oedema, haemorrhage, secondary pneumonia and lymphocytolysis. These pathologies bear marked similarity to primary pathologies observed during human disease. Therefore, this simple, small animal model will allow researchers to study the major pathologies observed in humans, while permitting experimentation in more widely available Biosafety Level 2 facilities.<\/jats:p>","DOI":"10.1111\/j.0959-9673.2006.00473.x","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T15:02:08Z","timestamp":1143558128000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Histopathology in a murine model of anthrax"],"prefix":"10.1111","volume":"87","author":[{"given":"Scott","family":"Duong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucius","family":"Chiaraviglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2291"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01794"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.25.3.268-273.1961"},{"key":"e_1_2_6_5_1","first-page":"457","article-title":"Human inhalation anthrax. 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