{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:49:47Z","timestamp":1780058987456,"version":"3.54.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Geri Cardiology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>Pulse pressure provides information beyond systolic and diastolic blood pressures, from which it is calculated. The majority of individuals older than 70 years have a widened pulse pressure resulting from age\u2010related stiffening of the central elastic arteries and systolic hypertension. A widened pulse pressure is associated with cardiovascular risk factors such as diabetes, hypertension, and smoking. It also predicts a higher risk of subsequent cardiovascular events, stroke, renal disease, heart failure, and mortality, particularly in the elderly. The authors review the mechanisms that contribute to pulse pressure and the association between pulse pressure, vascular risk factors, and outcomes.<\/jats:italic>\n          <\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1076-7460.2006.04774.x","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T20:03:55Z","timestamp":1169841835000},"page":"226-234","source":"Crossref","is-referenced-by-count":22,"title":["Pulse Pressure and Vascular Risk in the Elderly: Associations and Clinical Implications"],"prefix":"10.1111","volume":"15","author":[{"given":"Rajesh V.","family":"Swaminathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen P.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.354"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.7.634"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00687-2"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1245"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01108-1"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh121"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105767.94169.E3"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460240051027"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05381-6"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816120-00016"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000119354.41615.33"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.1.90"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199905000-00012"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.15.1504"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90305-0"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.6.1652"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.4.589"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.4.576"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00005"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000047464.66901.60"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01219-X"},{"key":"e_1_2_9_24_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0002-8703(98)70274-1","article-title":"Aortic stiffness in young patients with heterozygous familial hypercholesterolemia","volume":"135","author":"Pitsavos C","year":"1998","journal-title":"Am Heart J"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01723-0"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01717-5"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.335"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065222.34933.FC"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2003.00963.x"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200112000-00014"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.6.1385"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.381"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.096802"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.9.1183"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00006"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.3.375"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.092966"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000060127.96986.F4"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1548"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.9.1074"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07330-4"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01974-9"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02260-3"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.096212"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.23.1903"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)03259-4"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000069826.36125.B4"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.095774"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.3.524"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91064-O"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199100182-00035"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.097806"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715120-00069"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1992.tb01746.x"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2003.01751.x"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.9.1183"}],"container-title":["The American Journal of Geriatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1076-7460.2006.04774.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1076-7460.2006.04774.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1076-7460.2006.04774.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1076-7460.2006.04774.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T12:05:01Z","timestamp":1694433901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1076-7460.2006.04774.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1076-7460.2006.04774.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1076-7460.2006.04774.x","archive":["Portico"],"relation":{},"ISSN":["1076-7460","1751-715X"],"issn-type":[{"value":"1076-7460","type":"print"},{"value":"1751-715X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}