{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:15:15Z","timestamp":1770506115570,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,12,9]],"date-time":"2004-12-09T00:00:00Z","timestamp":1102550400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aim.\u2002<\/jats:bold> To assess the reliability of two different enzyme immunoassays in detecting the <jats:italic>Helicobacter pylori<\/jats:italic> status in stool specimens of Turkish patients with dyspepsia.<\/jats:p><jats:p><jats:bold>Materials and methods.\u2002<\/jats:bold> One hundred and fifty\u2010one patients [74 with nonulcer dyspepsia (NUD), 64 with duodenal ulcer (DU) and 13 with gastric cancer] who were admitted to the endoscopy unit of Istanbul University, Cerrahpasa Medical Faculty for upper gastrointestinal endoscopy because of dyspepsia were enrolled in the study. <jats:italic>Helicobacter pylori<\/jats:italic> infection was confirmed in all patients by histology, rapid urease test and culture. A patient was classified as being <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive if the culture alone or both the histology and the rapid urease test were positive and as negative only if all of these tests remained negative. Stool samples were obtained from patients to assess the reliability of a monoclonal (FemtoLab <jats:italic>H.\u00a0pylori<\/jats:italic>) and a polyclonal (Premier Platinum HpSA) stool antigen test and to compare the diagnostic accuracies of these two tests. A \u03c7<jats:sup>2<\/jats:sup> test was used for statistical comparisons.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Using cut\u2010off values of 0.19 for FemtoLab <jats:italic>H.\u00a0pylori<\/jats:italic> and 0.16 for Premier Platinum HpSA, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 93%, 90%, 98%, 68% and 93% for the monoclonal test and 84%, 67%, 94%, 40% and 81% for the polyclonal test, respectively. The sensitivity, specificity, negative predictive value and diagnostic accuracy of the monoclonal test were significantly greater than those of the polyclonal test (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a03.98; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 for sensitivity and \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a015.67; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000 for specificity, \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a015.78; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000 for negative predictive value and \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a06.37; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012 for diagnostic accuracy). The bacterial load did not affect the sensitivity of either test.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> The monoclonal FemtoLab <jats:italic>H pylori<\/jats:italic> test, using a cut\u2010off 0.19, is a very sensitive, specific and easy to perform diagnostic tool for the primary diagnosis of <jats:italic>H.\u00a0pylori<\/jats:italic> infection in Turkish patients with dyspepsia.<\/jats:p>","DOI":"10.1111\/j.1083-4389.2004.00280.x","type":"journal-article","created":{"date-parts":[[2004,12,9]],"date-time":"2004-12-09T14:03:31Z","timestamp":1102601011000},"page":"657-662","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of two Different Stool Antigen Tests for the Primary Diagnosis of <i>Helicobacter pylori<\/i> Infection in Turkish Patients with Dyspepsia"],"prefix":"10.1111","volume":"9","author":[{"given":"Y.","family":"Erzin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Altun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dobrucali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Erdamar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dirican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kocazeybek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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