{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:12:58Z","timestamp":1774260778712,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T00:00:00Z","timestamp":1128643200000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p><jats:bold>Abstract\u2003<\/jats:bold> Tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) is considered to play a critical role in the pathogenesis of immune\u2010mediated inflammatory demyelinating disorders of the peripheral nervous system (PNS). Processing of membrane\u2010bound inactive pro\u2010TNF\u2010\u03b1 into the active soluble cytokine is mediated by a sheddase, the so\u2010called TNF\u2010\u03b1\u2010converting enzyme (TACE), a member of the A Disintegrin and Metalloproteinase (ADAM) family. We explored the expression of TACE (ADAM\u201017) in sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an animal model of the Guillain\u2010Barr\u00e9 syndrome (GBS), an immune\u2010mediated polyradiculoneuropathy. To extend our study to human disease, sural nerve biopsies from GBS patients were investigated by immunohistochemistry. In EAN, T lymphocytes could be defined as the cellular source of ADAM\u201017 with peak expression levels at maximum clinical disease severity. Similarly, in human sural nerves, ADAM\u201017\u2010expressing T cells could be localized primarily within the epi\u2010 and perineurium, whereas in control sections from patients with non\u2010inflammatory neuropathies, no expression could be depicted. Our findings indicate that ADAM\u201017 is upregulated during EAN and expressed in nerves of GBS patients and thus may contribute to the pathogenesis of inflammatory demyelination of the PNS.<\/jats:p>","DOI":"10.1111\/j.1085-9489.2005.10309.x","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T08:24:36Z","timestamp":1128673476000},"page":"311-318","source":"Crossref","is-referenced-by-count":23,"title":["Tumor necrosis factor\u2010\u03b1\u2010converting enzyme is expressed in the inflamed peripheral nervous system"],"prefix":"10.1111","volume":"10","author":[{"given":"Martin","family":"Kurz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Pischel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Peter","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd C.","family":"Kieseier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01528-3"},{"key":"e_1_2_6_3_1","first-page":"667","article-title":"Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function\u2010associated antigen\u20101","volume":"70","author":"Archelos JJ","year":"1994","journal-title":"Lab 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