{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:48Z","timestamp":1791296688830,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":4352,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1111\/j.1087-0024.2004.00833.x","type":"journal-article","created":{"date-parts":[[2004,1,7]],"date-time":"2004-01-07T13:54:30Z","timestamp":1073483670000},"page":"34-40","source":"Crossref","is-referenced-by-count":78,"title":["Environmental Risk Factors in Endemic Pemphigus Foliaceus (Fogo Selvagem)"],"prefix":"10.1016","volume":"9","author":[{"given":"Valeria","family":"Aoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Millikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro A.","family":"Rivitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Hans-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.P.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Hilario-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond G.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0010","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.130.2.722","article-title":"Serological aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response","volume":"130","author":"Aalberse","year":"1983","journal-title":"J Immunol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/1523-1747.ep12472348","article-title":"Subclass reactivity of pemphigus foliaceus autoantibodies with recombinant human desmoglein","volume":"100","author":"Allen","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/1523-1747.ep12606168","article-title":"Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus","volume":"104","author":"Amagai","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0025","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0030","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI8748","article-title":"Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus","volume":"105","author":"Amagai","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0035","first-page":"293","article-title":"Penfigo foliaceo Sul-Americano no Estado de Goias","volume":"1","author":"Auad","year":"1972","journal-title":"Brazil Revista Patologia Trop"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3181\/00379727-127-32626","article-title":"Immunofluorescent studies of autoantibodies to intercellular areas of epithelia in Brazilian pemphigus foliaceus","volume":"127","author":"Beutner","year":"1968","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.121.3.481","article-title":"Nomenclature of the desmosomal cadherins","volume":"121","author":"Buxton","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/jaut.1993.1012","article-title":"Affinity immunoblotting studies on the restriction of autoantibodies from endemic pemphigus foliaceus patients","volume":"6","author":"Calvanico","year":"1993","journal-title":"J Autoimmunity"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0055","first-page":"208","article-title":"Pemphigus chronique, general forme rare do pemphigus foliace","volume":"1","author":"Cazenave","year":"1844","journal-title":"Ann Mal la Peu"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0060","series-title":"Parasitic Diseases","first-page":"190","article-title":"IV, Protozoa 30 Trypanosoma Cruzi (Chagas 1909)","author":"Despommier","year":"1995"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0190-9622(89)70079-7","article-title":"Endemic pemphigus foliaceus (fogo selvagem). I. Clinical features and immunopathology","volume":"20","author":"Diaz","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/1523-1747.ep13070394","article-title":"Endemic pemphigus foliaceus (fogo selvagem). II. Current and historic epidemiologic studies","volume":"92","author":"Diaz","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/jmedent\/35.2.120","article-title":"Comparison of black fly pecies (Diptera: Simuliidae) on an Amerindian reservation with a high prevalence of fogo selvagem to neighboring disease free sites in the State of Mato Grosso Do Sul, Brazil","volume":"35","author":"Eaton","year":"1998","journal-title":"J Med Entomol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/1523-1747.ep12665364","article-title":"Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1","volume":"104","author":"Emery","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/clin.1997.4407","article-title":"Mechanisms of acantholysis in pemphigus foliaceus","volume":"85","author":"Espa\u00f1a","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0090","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1084\/jem.165.6.1719","article-title":"Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients","volume":"165","author":"Eyre","year":"1987","journal-title":"J Exp Med"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0095","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI113387","article-title":"Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen","volume":"81","author":"Eyre","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0100","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0190-9622(95)91330-0","article-title":"Endemic pemphigus foliaceus (fogo selvagem) in Native Americans from Brazil","volume":"32","author":"Friedman","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0105","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0006-291X(05)80917-9","article-title":"Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules","volume":"173","author":"Goodwin","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0110","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthr Rheum"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12298213","article-title":"An active focus of high prevalence of fogo selvagem on an Amerindian reservation in Brazil","volume":"107","author":"Hans-Filho","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0120","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1083\/jcb.137.5.1091","article-title":"Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris","volume":"137","author":"Koch","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0125","first-page":"1","article-title":"Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules","volume":"53","author":"Koch","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/1523-1747.ep12316680","article-title":"Pemphigus sera recognize conformationally sensitive epitopes in the amino-terminal region of desmoglein-1","volume":"105","author":"Kowalczyk","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/1523-1747.ep12515943","article-title":"The calcium-sensitive epitope of pemphigus foliaceus antigen is present on a murine tryptic fragment and constitutes a major antigenic region for human autoantibodies","volume":"96","author":"Labib","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0140","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1172\/JCI8075","article-title":"Development and characterization of desmoglein-1 specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem)","volume":"105","author":"Lin","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0145","doi-asserted-by":"crossref","unstructured":"Li N, Aoki V, Hans-Filho G, Rivitti EA, Diaz LA:The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem). J Exp Med, in press","DOI":"10.1084\/jem.20022031"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0150","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/1523-1747.ep12456932","article-title":"Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem)","volume":"98","author":"Lombardi","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-065X.1998.tb01223.x","article-title":"Epitope spreading. The role of self peptide and autoantigen processing by B lymphocytes","volume":"164","author":"Mamula","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1600-065X.1998.tb01222.x","article-title":"Determinant spreading. Lesions from animal models and human disease","volume":"164","author":"McCluskey","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-0039.1997.tb02707.x","article-title":"An epitope in the third hypervariable region of the DRB1 gene is involved in the susceptibility to endemic pemphigus foliaceus (fogo selvagem) in three different Brazilian populations","volume":"49","author":"Moraes","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/archderm.1993.01680220081019","article-title":"Pemphigus foliaceus in young women. An endemic focus in the Sousse area of Tunisia","volume":"129","author":"Morini","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0175","first-page":"333","article-title":"Importance of IgG4 determination in in vitro immunotheraphy follow-up of inhalant allergens","volume":"8","author":"Oehling","year":"1998","journal-title":"Invest Allergol Clin Immunol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0180","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/1523-1747.ep12382794","article-title":"Pemphigus foliaceus sera recognize an N-terminal fragment of bovine desmoglein 1","volume":"102","author":"Olague-Alcala","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0185","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.4049\/jimmunol.134.4.2707","article-title":"Prominence of IgG4 in the IgG antibody response to human filariasis","volume":"134","author":"Ottesen","year":"1985","journal-title":"J Immunol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0190","series-title":"Contribuicao ao estudo do Tokelau (Doctoral Thesis)","author":"Paes-Leme","year":"1903"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0195","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1590\/S0074-02761999000700008","article-title":"Evolution of the clinical and epidemiological knowledge about Chagas diseases 90 years after its discovery","volume":"949","author":"Prata","year":"1999","journal-title":"Mem Inst Oswaldo Cruz, Rio Janeiro"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0200","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0190-9622(94)70263-2","article-title":"Pemphigus foliaceus autoantibodies bind both epidermis and squamous mucosal epithelium but tissue injury is detected only in the epidermis","volume":"31","author":"Rivitti","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0205","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1365-2133.1988.tb02590.x","article-title":"South American pemphigus foliaceus. Study of an epidemic in El Bagre and Nechi, Colombia 1982\u201386","volume":"118","author":"Robledo","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0210","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1172\/JCI114426","article-title":"Monovalent Fab\u2032 immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal BALB\/c mice","volume":"85","author":"Rock","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0215","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJM198906013202206","article-title":"The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem)","volume":"320","author":"Rock","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0220","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/1523-1747.ep12277362","article-title":"Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB\/c mice by passive transfer","volume":"85","author":"Roscoe","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0225","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.167.9.5439","article-title":"Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins","volume":"167","author":"Sekiguchi","year":"2001","journal-title":"J Immunol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0230","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1172\/JCI114036","article-title":"Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases","volume":"83","author":"Stanley","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0235","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1523-1747.ep12695334","article-title":"Antigenic specificity of fogo selvagem autoantibodies is similar to North American pemphigus foliaceus and distinct from pemphigus vulgaris autoantibodies","volume":"87","author":"Stanley","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0240","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0952-7915(96)80012-4","article-title":"Epitope spreading","volume":"8","author":"Vanderlugt","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0245","series-title":"Empresa Gr\u00e1fica Da Revista Dos Tribunais (Publisher)","article-title":"Contribui\u00e7\u00e3o ao estudo do Pemphigo no Estado de Sao Paulo","author":"Vieira","year":"1937"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0250","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1523-1747.2003.12017.x","article-title":"The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus","volume":"120","author":"Warren","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM200007063430104","article-title":"The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil","volume":"343","author":"Warren","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1087-0024.2004.00833.x_bb0260","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1073\/pnas.88.11.4796","article-title":"Desmosomal glycoprotein DGI, a component of intracellular desmosome junctions, is related to the cadherin family of cell adhesion molecules","volume":"88","author":"Wheeler","year":"1991","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15529795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15529795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:44:50Z","timestamp":1705009490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15529795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0022202X15529795"],"URL":"https:\/\/doi.org\/10.1111\/j.1087-0024.2004.00833.x","relation":{},"ISSN":["1087-0024"],"issn-type":[{"value":"1087-0024","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}