{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:03:20Z","timestamp":1758272600857},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":5761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, <jats:italic>e.g.<\/jats:italic>, dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis. The pathophysiology and treatment of MTX nodulosis are yet unsettled. We experienced a case with dermatomyositis who developed multiple subcutaneous nodules after treatment with MTX. In our patient, numerous, small, symmetrically distributed, grouped subcutaneous nodules were seen on a V\u2010shaped area of the anterior chest, both axillary areas, and the medial sides of both upper arms and thighs. We histopathologically examined a nodule and started treatment with hydroxychlroquine after discontinuation of MTX. The histopathology revealed septal panniculitis, and the nodules have been under regression.<\/jats:p><jats:p>MTX nodulosis may be a drug\u2010specific phenomenon. Discontinuation of MTX and replacement with hydroxychloroquine are recommended in severe cases. Awareness of this entity is important for diagnosing and treating cases of multiple nodules developing after the administration of MTX, which is widely used for many dermatological diseases.<\/jats:p>","DOI":"10.1111\/j.1346-8138.1999.tb02027.x","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T07:26:35Z","timestamp":1428650795000},"page":"460-464","source":"Crossref","is-referenced-by-count":13,"title":["Methotrexate Nodulosis"],"prefix":"10.1111","volume":"26","author":[{"given":"Kyoung\u2010Ae","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee\u2010Chan","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Jeh","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai\u2010Kyoung","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310915"},{"key":"e_1_2_1_3_1","first-page":"867","article-title":"Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases","volume":"19","author":"Kerstens PJ","year":"1992","journal-title":"J Rhematol"},{"key":"e_1_2_1_4_1","first-page":"153","article-title":"Accelerated nodulosis and systemic manifestations during methotrexate therapy for rheumatoid arthritis","volume":"2","author":"Combe B","year":"1993","journal-title":"Eur J Med"},{"key":"e_1_2_1_5_1","first-page":"755","article-title":"Possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis","volume":"20","author":"Combe B","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.7.480-b"},{"key":"e_1_2_1_7_1","first-page":"934","article-title":"Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy","volume":"21","author":"Abu\u2010Shakra M","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_1","first-page":"2359","article-title":"Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy","volume":"22","author":"Smith MD","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_1","first-page":"1223","article-title":"Detailed immunohistologic evaluation of a methotrexate\u2010induced nodule","volume":"118","author":"DiFrancesco L","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)80139-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400122"},{"key":"e_1_2_1_12_1","first-page":"2359","article-title":"Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate","volume":"22","author":"Berris B","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_1","first-page":"2004","article-title":"Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate","volume":"23","author":"Smith MD","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_1_14_1","first-page":"1960","article-title":"Rheumatoid nodulosis of the meninges","volume":"21","author":"Karan NE","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360121"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90787-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(95)80034-4"},{"key":"e_1_2_1_18_1","first-page":"847","volume-title":"Lever's Histopathology of the Skin","author":"Jaworsky C","year":"1997"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331102"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.2.86"},{"key":"e_1_2_1_21_1","first-page":"756","article-title":"Possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis","volume":"20","author":"Kerstens PJ","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400716"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.1999.tb02027.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.1999.tb02027.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.1999.tb02027.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T23:56:20Z","timestamp":1698537380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.1999.tb02027.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1111\/j.1346-8138.1999.tb02027.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.1999.tb02027.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}