{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:03:46Z","timestamp":1778947426477,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":5517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (BP), an autoimmune skin disease of the elderly, is mediated by autoantibodies that bind to hemidesmosomes of epidermal basal cells. This study investigated BP\u2010associated HLA\u2010DR and \u2010DQ genes among Japanese patients. We analyzed HLA\u2010DR and \u2010DQ genes among 23 Japanese BP patients based on the polymerase chain reaction\u2010restriction fragment length polymorphism. Eighteen of these 23 patients (78%) carried at least one allele of HLA\u2010DRB1<jats:sup>*<\/jats:sup>04 or DRB1<jats:sup>*<\/jats:sup>1101, with significant increases in HLA\u2010DRB1<jats:sup>*<\/jats:sup>04 (<jats:sup>*<\/jats:sup>0403, <jats:sup>*<\/jats:sup>0406)\/DQA1<jats:sup>*<\/jats:sup>0301\/DQB1<jats:sup>*<\/jats:sup>0302 and DRB1<jats:sup>*<\/jats:sup>1101\/DQA1<jats:sup>*<\/jats:sup>0505\/DQB1<jats:sup>*<\/jats:sup>0302 haplotypes as well as the individual alleles DRB1<jats:sup>*<\/jats:sup>1101 and DQB1<jats:sup>*<\/jats:sup>0302 (corrected p&lt;0.05 for each comparison), when compared to control subjects. These data differ from the accepted DQB1<jats:sup>*<\/jats:sup>0301 (DQ7) association with the same disease among Caucasians. These findings indicate that different HLA class II haplotypes genetically influence susceptibility to BP among different ethnic groups. Our findings, together with previous reports on Caucasian patients with the pemphigoid group of bullous diseases, suggest that HLA\u2010DRB1 molecules might participate in the regulation of autoimmune responses to BP antigens.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2000.tb02141.x","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T06:10:09Z","timestamp":1428646209000},"page":"149-156","source":"Crossref","is-referenced-by-count":57,"title":["Polymorphisms of HLA\u2010DR and \u2010DQ Genes in Japanese Patients with Bullous Pemphigoid"],"prefix":"10.1111","volume":"27","author":[{"given":"Aiko","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Yamashina","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University  Nara 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