{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:13:50Z","timestamp":1779221630329,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":5425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of toxic epidermal necrolysis\u2010type drug eruption. A 23\u2010year\u2010old man took an oral over\u2010the\u2010counter preparation for the common cold. A few days later, generalized erythema developed with systemic malaise and pain. A multiple blister formation followed, and Nikolsky's sign was noted on each blister. A lymphocyte stimulation test (LST) with the patient's peripheral lymphocytes strongly suggested that the eruption was attributable to lysozyme chloride which was included in the preparation taken. Follwing an intravenous drip of betamethasone for two weeks, the eruptions improved favorably.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2000.tb02191.x","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T06:25:14Z","timestamp":1428647114000},"page":"401-404","source":"Crossref","is-referenced-by-count":7,"title":["A Case of Toxic Epidermal Necrolysis\u2010Type Drug Eruption Induced by Oral Lysozyme Chloride"],"prefix":"10.1111","volume":"27","author":[{"given":"Miwa","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health  Japan (Director, Prof. M. Asahi)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health  Japan (Director, Prof. M. Asahi)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health  Japan (Director, Prof. M. Asahi)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Asahi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health  Japan (Director, Prof. M. Asahi)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"e_1_2_1_4_1","first-page":"1249","article-title":"A clinical study of 126 cases of toxic epidermal necrolysis in Japan","volume":"33","author":"Nanko H","year":"1991","journal-title":"rinsho derma"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens\u2010Johnson syndrome, and erythema multiforme","volume":"129","author":"Garin SB","year":"1993","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_6_1","first-page":"136","article-title":"Specific IgE antibody titers to hen's egg white lysozyme in allergic children to egg","volume":"42","author":"Yamada T","year":"1993","journal-title":"Allergy"},{"key":"e_1_2_1_7_1","first-page":"1790","article-title":"Hypersensitivity of patients with egg allergy to ovalbumin, ovomucoid and lysozyme","volume":"47","author":"Miyake T","year":"1984","journal-title":"J Pediatric Practice"},{"key":"e_1_2_1_8_1","first-page":"444","article-title":"Contact urticaria to hen egg white lysozyme preparations","volume":"27","author":"Matsuyama T","year":"1985","journal-title":"Hifu"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00690.x"},{"key":"e_1_2_1_10_1","first-page":"521","article-title":"Allergy to lysozyme\/egg white\u2010containing vaginal suppositories","volume":"69","author":"Pichler WJ","year":"1992","journal-title":"Ann Allergy"},{"key":"e_1_2_1_11_1","first-page":"95","article-title":"Diagnosis of drug eruption by using lymphocyte stimulation tests","volume":"27","author":"Ichikawa S","year":"1985","journal-title":"rinsho derma"},{"key":"e_1_2_1_12_1","unstructured":"Policy Planning and Evaluation Division:Statistics of Production by Pharmaceutical Industry 1997."}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2000.tb02191.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2000.tb02191.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:19:52Z","timestamp":1698599992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2000.tb02191.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1111\/j.1346-8138.2000.tb02191.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2000.tb02191.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}