{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T20:36:54Z","timestamp":1720471014937},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T00:00:00Z","timestamp":1147651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Behcet's disease is a chronic multisystemic disease of unknown pathogenesis characterized by four major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. The disease is spread throughout the world, but it is most frequent in Turkey, Japan, Korea and China. Although HLA\u2010Bw51 has been found to predominate in Behcet's cases, the genetic etiology has not yet been clarified. In this study, we investigated the chromosomal abnormalities and sister chromatid exchange rates in patients with Behcet's diseases. Thirty\u2010eight patients with Behcet's disease (diagnosed for the first time) and 30 healthy subjects (as controls) were included in this study. Although numerical and structural chromosomal abnormalities were not detected in our patients, we found an increased rate of sister chromatid exchange in patients over the control groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). On the basis of these results, we discuss the genetic etiology of Behcet's disease.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2006.00096.x","type":"journal-article","created":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T09:39:54Z","timestamp":1147685994000},"page":"406-410","source":"Crossref","is-referenced-by-count":5,"title":["Chromosome and sister chromatid exchange studies in Behcet's patients"],"prefix":"10.1111","volume":"33","author":[{"given":"Sitki","family":"OZTAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulay","family":"GULLULU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulgani","family":"TATAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"ASTAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur","family":"AKYOL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"KARAKUZU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akin","family":"AKTAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Riza","family":"ODABAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Behcet's Syndrome","author":"Online Mendelian Inheritance In Man (OMIM#","year":"2005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-004-0033-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400302"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00265-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040433013"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01060.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.5.935"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1298"},{"key":"e_1_2_5_10_2","first-page":"3702","article-title":"Localization of the pathogenic gene of Behcet's disease by microsatellite analysis of three different populations","volume":"41","author":"Mizuki N","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600506.x"},{"key":"e_1_2_5_12_2","first-page":"1207","article-title":"Chromosome aberration in lymphocytes from Behcet's disease","volume":"18","author":"Takeuchi F","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","first-page":"416","article-title":"Intestinal Behcet's disease associated with myelodysplastic syndrome with chromosomal trisomy 8; 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