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Real\u2010time reverse transcription polymerase chain reaction (RT\u2013PCR) and gelatin zymography were used to detect and quantify the expression of MMP\u20102 by these different kinds of cells. In independent cultures, MMP\u20102 was highly expressed by fibroblasts and melanoma cells constitutively, but barely expressed by keratinocytes and basal cell carcinoma (BCC) cells. MMP\u20102 expression by fibroblasts was downregulated in co\u2010cultures with keratinocytes or BCC cells, but not with melanoma cells. These results indicate that epidermal\u2013mesenchymal interactions are important modulators for MMP\u20102 expression by cutaneous cells and suggest a host\u2010defense mechanism against the tumor progression of BCC.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2006.00141.x","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T08:24:56Z","timestamp":1157444696000},"page":"609-615","source":"Crossref","is-referenced-by-count":9,"title":["Differential expression of matrix metalloproteinase\u20102 by fibroblasts in co\u2010cultures with keratinocytes, basal cell carcinoma and 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