{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:33:02Z","timestamp":1790346782317,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We performed a pilot study to assess the safety and efficacy of pulse therapy with terbinafine tablets in 66 patients with dermatophyte onychomycosis. One pulse consisted of oral terbinafine tablets (500\u00a0mg\/day) given for 1\u00a0week followed by a 3\u2010week interval. Topical 1% terbinafine cream was applied daily. The number of pulses was determined by the extent of improvement in the affected nails and by the patient's requests, up to a maximum of six pulses. Efficacy was assessed based on both clinical and mycological examinations 1\u00a0year after treatment initiation. We observed a complete cure in 51 patients (77.3%), marked improvement in five patients (7.6%), improvement in five patients (7.6%) and slight improvement in one patient (1.5%). Four patients (6.0%) showed no change. In the patients who were completely cured, the average number of pulses used was 3.7\u00a0\u00b1\u00a01.4 pulses and the treatment duration was 3.3\u00a0\u00b1\u00a01.6\u00a0months. Nine patients experienced adverse effects, consisting of gastrointestinal disturbance (eight patients) and drug\u2010induced eruption (one patient). There were no abnormal findings in the laboratory tests, including liver function tests. In summary, terbinafine pulse therapy in combination with topical application of terbinafine cream appeared safe and effective in this pilot study.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2006.00176.x","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T07:57:30Z","timestamp":1161935850000},"page":"753-758","source":"Crossref","is-referenced-by-count":15,"title":["Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: A pilot study"],"prefix":"10.1111","volume":"33","author":[{"given":"Naomi","family":"NAKANO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataro","family":"HIRUMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"SHIRAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarawan","family":"PORGPERMDEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigaku","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00628.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110644"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2340\/000155557300304","article-title":"Levels of terbinafine in plasma, stratum corneum, dermisepidermis (without stratum corneum), sebum, hair and nails during and after 250\u00a0mg terbinafine orally once per day four weeks","volume":"73","author":"Faergemann J","year":"1993","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80057-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1996.tb04009.x"},{"key":"e_1_2_5_7_2","first-page":"1253","article-title":"Intermittent terbinafine for toenail onychomycosis: is it effective? Result of a randomized pilot trial","volume":"137","author":"Warshaw EM","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410035329"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.691"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304010-00005"},{"key":"e_1_2_5_11_2","first-page":"6","article-title":"The scoring clinical index for onychomycosis (SCIO Index)","volume":"6","author":"Sergeev AY","year":"2001","journal-title":"Skin Therapy Letter Editor Dr Stuart Maddin May"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70397-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01273.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00051.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01678.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.1.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2133.2003.05381.x","article-title":"A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis","volume":"149","author":"Rigopoulos D","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2133.2001.00047.x","article-title":"The rationale for combination therapy","volume":"145","author":"Evans EG","year":"2001","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2133.2001.00045.x","article-title":"Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine, a cost\u2010effective treatment for onychomycosis","volume":"145","author":"Baran R","year":"2001","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00025-1"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.56.809"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2006.00176.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2006.00176.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:58:38Z","timestamp":1697180318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2006.00176.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,27]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1346-8138.2006.00176.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2006.00176.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,27]]}}}