{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:36:46Z","timestamp":1775687806149,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lichen sclerosus is a chronic inflammatory skin disorder that has a predilection for the anogenital area. Topical corticosteroid is occasionally effective; however, continuous treatment is often required and recurrence after its stoppage is frequent. Herein, we report a case of vulvar lichen sclerosus in a 5\u2010year\u2010old girl, which was refractory to topical corticosteroids. After 14\u00a0weeks of treatment with 0.03% tacrolimus ointment once daily, the lesions completely resolved without side\u2010effects. Of interest, the number of milia within the plaque of lichen sclerosus was reduced in tandem with the improvement of lichen sclerosus. This is the first report of topical low\u2010concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2006.00228.x","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T16:27:06Z","timestamp":1168964826000},"page":"114-116","source":"Crossref","is-referenced-by-count":20,"title":["Successful treatment of vulvar lichen sclerosus in a child with low\u2010concentration topical tacrolimus ointment"],"prefix":"10.1111","volume":"34","author":[{"given":"Yuka","family":"MATSUMOTO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"ISOBE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"KUSUNOKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"TSUBOI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00247.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113474"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03360.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.8"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.850"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.922"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.709"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb00626.x"},{"key":"e_1_2_4_10_2","first-page":"790","article-title":"Lichen sclerosus: therapy with clobetasol propionate","volume":"43","author":"Lorenz B","year":"1998","journal-title":"J Reprod Med"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.5.525"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01496-X"},{"key":"e_1_2_4_13_2","first-page":"706","article-title":"Childhood vulvar lichen sclerosus: the course after puberty","volume":"47","author":"Powell J","year":"2002","journal-title":"J Reprod Med"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.702"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2006.00228.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2006.00228.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:45:27Z","timestamp":1697226327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2006.00228.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,16]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1346-8138.2006.00228.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2006.00228.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,16]]}}}