{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:36:05Z","timestamp":1790094965237,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T00:00:00Z","timestamp":1221868800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aim of the present study was to analyze the characteristics of atopic dermatitis (AD) in the senile phase. Subjects were comprised of 16 patients investigated for clinical features, serum immunoglobulin (Ig)E levels and skin manifestations. Mean age was 76.9\u00a0\u00b1\u00a06.2\u00a0years (range, 68\u201387), with a man\u00a0:\u00a0woman ratio of 3:1. Mean age at onset was 67.7\u00a0\u00b1\u00a015.7\u00a0years. Eight patients (50%) had personal histories of chronic eczema until the young adult phase and three patients (18.8%) showed the classic course of child AD. Eczematous erythroderma in 10 patients (62.5%) and unclassified chronic eczema in five patients (31.3%) were the predominant clinical presentations. Mean total IgE level in sera of the 16 patients was 8810\u00a0\u00b1\u00a013\u00a0511 IU\/mL (range, 5\u201353\u00a0605). Fourteen patients showed positive results for antigen\u2010specific IgE antibodies, and the mean total IgE level for these patients was 10\u00a0056\u00a0\u00b1\u00a014\u00a0044\u00a0IU\/mL. Specific IgE to the main antigen, <jats:italic>Dermatophagoides farinae<\/jats:italic>, was observed in 12 patients (85.7%), representing the principal antibody in eight patients (57.1%). Eczematous dermatitis manifested predominantly in the face and neck, trunk and extensor and flexure sites of extremities, and less commonly in the antecubital and popliteal areas. Other stigmata of AD were observed as follows: red face in 10 patients (62.5%); Hertoghe's sign in six (37.5%); goose\u2010skin in four (25%); facial pallor in three (18.8%); and dirty neck in one (6.3%). These results indicate that senile\u2010type AD represents a characteristic subgroup of AD that appears in the last stage of life in AD patients.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2008.00524.x","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T07:20:36Z","timestamp":1221895236000},"page":"562-569","source":"Crossref","is-referenced-by-count":51,"title":["Clinical analyses of atopic dermatitis in the aged"],"prefix":"10.1111","volume":"35","author":[{"given":"Ryoji","family":"TANEI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"KATSUOKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01088.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02671-7_15"},{"key":"e_1_2_5_4_2","first-page":"42","volume-title":"Comprehensive Handbook of Clinical Dermatology 3","author":"Furue M.","year":"2002"},{"key":"e_1_2_5_5_2","first-page":"1095","article-title":"[Senile type atopic dermatitis.]","volume":"99","author":"Kawashima T","year":"1989","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin JM","year":"1980","journal-title":"Acta Dermatovener (Stockh)"},{"key":"e_1_2_5_7_2","first-page":"966","article-title":"Japanese Dermatological Association Criteria for the diagnosis of atopic dermatitis","volume":"22","author":"Scientific committee of the Japanese Dermatological Association","year":"1995","journal-title":"J Dermatol"},{"key":"e_1_2_5_8_2","first-page":"13","article-title":"Grading of the severity of atopic dermatitis","volume":"144","author":"Rajka G","year":"1989","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/clinchem\/31.9.1500","article-title":"Simultaneous determination of total IgE and allergen\u2010specific IgE in serum by the MAST chemiluminescent assay system","volume":"31","author":"Brown CR","year":"1985","journal-title":"Clin Chem"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235294"},{"key":"e_1_2_5_11_2","first-page":"68","volume-title":"Handbook of Gerontology 14","author":"Kojima R.","year":"1984"},{"key":"e_1_2_5_12_2","volume-title":"[A Diagram of Atopic Dermatitis]","author":"Uehara M.","year":"1980"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2008.00524.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2008.00524.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T02:21:50Z","timestamp":1697163710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2008.00524.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1111\/j.1346-8138.2008.00524.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2008.00524.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}