{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:22:45Z","timestamp":1791958965298,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. But the clinical efficacy of topical tacrolimus, a newly developed calcineurin inhibitor on seborrheic dermatitis, is not well investigated yet. We wanted to compare the clinical efficacy of topical tacrolimus with that of conventional treatment (zinc pyrithione shampoo and topical betamethasone) for treatment of seborrheic dermatitis of the scalp. Patients with seborrheic dermatitis of the scalp were randomly allocated to receive topical betamethasone, topical tacrolimus or zinc pyrithione shampoo. Some patients were instructed to continue the treatments for 8\u00a0weeks and the others to discontinue the treatments at week\u00a04. We evaluated the efficacy using a clinical severity score, dandruff score and sebum secretion at baseline, week\u00a04 and week\u00a08. All treatment groups showed significant improvements in clinical assessment after 4\u00a0weeks. While the patients treated by zinc pyrithione improved continuously even after cessation of the treatment, the patients treated by betamethasone lotion or tacrolimus ointment were aggravated clinically. Topical tacrolimus was as effective as topical betamethasone, and showed more prolonged remission than topical betamethasone. To treat seborrheic dermatitis of the scalp, we think that the combination therapy of topical steroid or topical tacrolimus, and zinc pyrithione is recommended.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2009.00607.x","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T07:55:03Z","timestamp":1237276503000},"page":"131-137","source":"Crossref","is-referenced-by-count":40,"title":["Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: A comparative study"],"prefix":"10.1111","volume":"36","author":[{"given":"Hyoseung","family":"SHIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Sang","family":"KWON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hyun","family":"WON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Joon","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Won","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Beom","family":"CHOE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Joong","family":"AHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Chul","family":"EUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125001875"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/aem.61.9.3385-3390.1995","article-title":"Mechanism of pyrithione\u2010induced membrane depolarization in Neurospora crassa","volume":"61","author":"Ermolayeva E","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2005.00354.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120942"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06208.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00938.x"},{"key":"e_1_2_6_8_2","first-page":"397","article-title":"Clobetasol propionate shampoo 0.05% in the treatment of seborrheic dermatitis of the scalp: results of a pilot study","volume":"79","author":"Reygagne P","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.450"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199612050-00003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.3.643"},{"key":"e_1_2_6_12_2","first-page":"83","article-title":"Correlation between Malassezia spp load and dandruff severity","volume":"8","author":"Pierard\u2010Franchimont C","year":"1998","journal-title":"J Myco Med"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70140-D"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2009.00607.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2009.00607.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:17:12Z","timestamp":1697174232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2009.00607.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1111\/j.1346-8138.2009.00607.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2009.00607.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}