{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T21:51:32Z","timestamp":1725486692423},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrent digital ulcers are manifestations of vascular disease in patients with systemic sclerosis (SSc). We report six patients with severe digital ulcers who were treated with bosentan administered p.o., 62.5\u2013125\u2003mg daily. The mean duration from the diagnosis of SSc to the initiation of bosentan was 9.5\u2003years, and the observation period after bosentan administration was from 7\u2003months to 4.5\u2003years. In case 1, neither new digital ulcers nor Raynaud\u2019s phenomenon developed for 4.5\u2003years. In case 2, digital ulcers recurred after the discontinuation of bosentan; however, re\u2010administration of bosentan lead to the improvement. In cases 3\u20135 with recurrent digital ulcers, no new lesions have developed. In these five patients, pain evaluated by visual analog scale was significantly reduced. In three patients, bosentan was discontinued because of severe liver dysfunction. These results suggest that bosentan is an effective treatment for refractory digital ulcers associated with SSc; however, liver function should be carefully monitored. Compared to the doses of bosentan used to treat pulmonary hypertension, relatively lower doses may effectively control painful digital ulcer\/gangrene in patients with SSc.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2011.01299.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T13:01:42Z","timestamp":1317214902000},"page":"48-51","source":"Crossref","is-referenced-by-count":11,"title":["Bosentan for digital ulcers in patients with systemic sclerosis"],"prefix":"10.1111","volume":"39","author":[{"given":"Yayoi","family":"NAGAI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"HASEGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"HATTORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"OKADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"TAGO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"ISHIKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/10489160-000000000-00000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380309"},{"key":"e_1_2_5_4_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"Leroy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_5_5_2","first-page":"715","article-title":"Generalized morphea\u2010like systemic sclerosis; a subtype of diffuse cutaneous systemic sclerosis presenting with unusual cutaneous features","volume":"18","author":"Nagai Y","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.073684"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel290"},{"key":"e_1_2_5_8_2","first-page":"90","article-title":"Bosentan reduces the number of new digital ulcses in patients with systemic sclerosis","volume":"65","author":"Seibold JR","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_5_9_2","article-title":"Bosentan reduces the number of new digital ilcers in patients with systemic sclerosis: open label extension to a double\u2010blind trial","volume":"65","author":"Black C","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20676"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080992"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken001"},{"key":"e_1_2_5_13_2","first-page":"190","article-title":"Severe liver dysfunction due to bosentan in a patient with mixed connective tissue disease","volume":"18","author":"Nagai Y","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq097"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07475.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2011.01299.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2011.01299.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T15:06:50Z","timestamp":1694444810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2011.01299.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1346-8138.2011.01299.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01299.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}