{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:03:34Z","timestamp":1788001414712,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aquaporin (AQP)\u20105 has been shown to be expressed in the secretory parts of mouse, rat and horse sweat glands. However, the precise localization of AQP\u20105 in normal and diseased human skin has not been fully determined. The aim of the present study was to further clarify the immunolocalization of AQP\u20105 in normal human skin and hypohidrotic skin diseases. Normal human scalp skin and biopsies from skin affected by hypohidrotic diseases were analyzed for AQP\u20105 and\/or dermcidin expression by immunohistochemistry, immunofluorescence and\/or immunoelectronmicroscopy. AQP\u20105 was expressed on the apical and basolateral plasma membranes of the clear cells in eccrine sweat coils, but not in ductal components or apocrine glands. Numbers of AQP\u20105\u2010positive coils in the secretory part of eccrine sweat glands were decreased in Sj\u00f6gren\u2019s syndrome, but not in skin affected by idiopathic segmental anhidrosis or idiopathic pure sudomotor failure. AQP\u20105 was mostly localized to the plasma membranes of clear cells in the secretory coils of eccrine sweat glands, suggesting that it plays a role in producing the primary sweat fluid.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2011.01327.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T06:42:53Z","timestamp":1317192173000},"page":"344-349","source":"Crossref","is-referenced-by-count":18,"title":["Immunolocalization of aquaporin\u20105 in normal human skin and hypohidrotic skin diseases"],"prefix":"10.1111","volume":"39","author":[{"given":"Takashi","family":"IIZUKA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"NAKANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"SUEKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.5.C1549"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.020180"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012588099"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00498.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.023"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04140-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780221"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni732"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06081.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_5_12_2","first-page":"A1156","article-title":"Cell specific co\u2010localisation of NKCC1 to cells in the human eccrine sweat gland already expressing AQP\u20105, H\u2010ATPase and carbonic anhydrase II (abstract)","volume":"19","author":"Bovell DL","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_5_13_2","first-page":"250","article-title":"Immunohistochemical localization of carbonic anhydrase I and II in eccrine sweat glands from control subjects and patients with cystic fibrosis","volume":"112","author":"Briggman JV","year":"1983","journal-title":"Am J Pathol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:HIJO.0000039837.45595.a6"},{"key":"e_1_2_5_15_2","first-page":"7","volume-title":"Lever\u2019s Histopathology of the Skin","author":"Velazquez EF","year":"2009"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02744.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)80070-1"},{"key":"e_1_2_5_19_2","first-page":"33","article-title":"A contribution to the pathology of Sj\u00f6gren\u2019s disease","volume":"20","author":"Ellman P","year":"1951","journal-title":"Q J Med"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000254034"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510150042010"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142036.54112.57"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1346-8138.2011.01327.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1346-8138.2011.01327.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:16:24Z","timestamp":1698700584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1346-8138.2011.01327.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1346-8138.2011.01327.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01327.x","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}