{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:28:42Z","timestamp":1762079322426},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 58\u2010year\u2010old Japanese man with a 2\u2010year history of multidrug therapy for borderline lepromatous leprosy presented with skin lesions suggestive of erythema nodosum leprosum (ENL) and was treated with an oral corticosteroid. As attempts to taper the oral corticosteroid resulted in the appearance of new lesions, thalidomide was added along with cyclosporin. Two months after the introduction of thalidomide, deep venous thrombosis (DVT) occurred in both legs and anticoagulant therapy was started without cessation of thalidomide. Pulmonary embolism developed 1\u2003month after the appearance of DVT, and these thromboembolic events were believed to be due to thalidomide. This case highlights the need for vigilance against venous thromboembolism when corticosteroid and thalidomide are co\u2010administrated for the treatment of ENL.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2011.01484.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T14:26:27Z","timestamp":1330439187000},"page":"711-714","source":"Crossref","is-referenced-by-count":9,"title":["Deep venous thrombosis and pulmonary embolism secondary to co\u2010administration of thalidomide and oral corticosteroid in a patient with leprosy"],"prefix":"10.1111","volume":"39","author":[{"given":"Sayaka","family":"YAMAGUCHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"HOSOKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"HAGIWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"UEZATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06747.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.348"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.03902.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.01.004"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01645-3"},{"key":"e_1_2_4_7_2","first-page":"270","article-title":"Risk factors for erythema nodosum leprosum","volume":"67","author":"Manandhar R","year":"1999","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.868"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.072"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.338-381.2006"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196563303"},{"key":"e_1_2_4_12_2","first-page":"135","article-title":"Results of a double blind study of the influence of thalidomide on the lepra reaction","volume":"37","author":"Sheskin J","year":"1969","journal-title":"Int J Lepr"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00534.x"},{"key":"e_1_2_4_14_2","first-page":"719","article-title":"WHO co\u2010ordinated short\u2010term double\u2010blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients","volume":"45","author":"Iyer CG","year":"1971","journal-title":"Bull World Health Organ"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12565.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1160\/TH06-09-0494","article-title":"Thalidomide and thrombosis. 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