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In this study, we performed immunohistochemical staining of 31 cases of basal cell carcinoma (BCC); 20 cases of trichoblastoma (TB), including ten cases of nodular type, eight cases of cribriform type (trichoepithelioma) and two cases of columnar type (desmoplastic trichoepithelioma); 16 cases of actinic keratosis (AK); and 10 cases each of Bowen\u2019s disease, poroma and seborrheic keratosis. Six cases of BCC and AK were co\u2010lesions of both neoplasms. In normal skin tissue, Ber\u2010EP4 reacted positively with the secretory portion of eccrine glands and follicular germinative cells at the lower end of catagen hairs. Neoplastic cells in 97% of cases with BCC reacted positively with Ber\u2010EP4 in at least 5% of neoplastic cells. Those in 90% with nodular type TB and 50% with trichoepithelioma also reacted positively in at least 5% of neoplastic cells. No cases of poroma, seborrheic keratosis, AK or Bowen\u2019s disease were immunohistochemically positive for Ber\u2010EP4 in neoplastic cells. In all six cases with co\u2010lesions of BCC and AK, neoplastic cells of BCC reacted positively with Ber\u2010EP4 and those of AK were negative. Immunohistochemical examination using the Ber\u2010EP4 antibody is a useful tool for diagnosing neoplasms with follicular germinative differentiation, such as TB, TE or BCC, and for differentiating those from squamous cell carcinoma <jats:italic>in situ<\/jats:italic>, poroma or seborrheic keratosis.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2011.01494.x","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T11:31:35Z","timestamp":1328182295000},"page":"688-692","source":"Crossref","is-referenced-by-count":41,"title":["Ber\u2010EP4 is a useful marker for follicular germinative cell differentiation of cutaneous epithelial 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