{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:46:57Z","timestamp":1791323217138,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T00:00:00Z","timestamp":1333584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Buruli ulcer (BU) is a new emerging disease and the third most common chronic mycobacterial infection in humans, caused by <jats:italic>Mycobacterium ulcerans<\/jats:italic>. Approximately 5000 cases are reported annually from at least 33 countries around the globe, but more from the tropical nations. A total of 32 cases have been reported from Japan sporadically since 1980. None of the cases were related to international travel. Of the total reported, <jats:italic>M.\u00a0ulcerans<\/jats:italic> ssp. <jats:italic>shinshuense<\/jats:italic>, a subspecies speculated to be domestic to Japan or in Asia, has been isolated from 23 cases. The mode of transmission and its incubation period remain unclear, despite several proposed hypotheses, including several vectors and cutaneous wound as port of entry for the pathogen. <jats:italic>M.\u00a0ulcerans<\/jats:italic> invades the skin, subcutaneous tissue, fascia and eventually forms extensive ulceration. Smear, culture, histopathology and polymerase chain reaction are established diagnostic tools to identify <jats:italic>M.\u00a0ulcerans<\/jats:italic>. Multiple antimicrobial therapy is a commonly used therapeutic method, but patients often need extensive debridement and, at times, skin grafting, especially when diagnosis is delayed. Thus, expanding a system for improved awareness and diagnosis in Japan and Asia is important, together with elucidating the candidate vector and the mode of transmission. Here, to establish a base for future progress in better understanding of this infectious disease, we reviewed the characteristics of the disease together with an update of reported cases in Japan.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01543.x","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T07:08:30Z","timestamp":1333609710000},"page":"587-593","source":"Crossref","is-referenced-by-count":32,"title":["Buruli ulcer and current situation in Japan: A new emerging cutaneous <i>Mycobacterium<\/i> infection"],"prefix":"10.1111","volume":"39","author":[{"given":"Rie R.","family":"YOTSU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"NAKANAGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"HOSHINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"ISHII","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"e_1_2_14_2_2","unstructured":"Global Buruli Ulcer Initiative (GBUI) World Health Organization.Buruli ulcer endemic countries [Internet]. 2011 [cited 2011 Nov 11]. 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