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Ear swelling after UV\u2010B irradiation was significantly reduced in TRX\u2010transgenic mice compared to wild\u2010type mice. Administration i.p. of recombinant human TRX also reduced acute skin inflammatory reaction, such as skin erythema and swelling. Histologically, numbers of inflammatory cells including neutrophils and lymphocytes were significantly reduced and the average size of the caliber of blood vessels were also reduced in recombinant human TRX\u2010injected mice. The number of apoptotic keratinocytes, in terms of sunburn cells, activated\u2010caspase\u20103\u2010positive cells and terminal deoxynucleotidyl transferase dUTP nick end labeling\u2010positive cells were all significantly reduced in recombinant human TRX\u2010injected mice. Immunohistochemical intensity of 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine was strikingly reduced in recombinant human TRX\u2010injected mouse. Western blotting showed that administration of recombinant human TRX attenuated duration of phosphorylation of p38 mitogen\u2010activated protein kinases and intensity of phosphorylation of c\u2010Jun N\u2010terminal kinase in the early phase, which play important roles in inflammatory and apoptotic signaling. Collectively, these findings indicated that recombinant human TRX attenuated inflammatory and apoptotic responses caused by UV\u2010B. Possible mechanisms for this might be via redox regulation of stress signaling and reduction of reactive oxygen species.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01566.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T09:10:40Z","timestamp":1336554640000},"page":"843-851","source":"Crossref","is-referenced-by-count":24,"title":["Suppressive effect of recombinant human thioredoxin on ultraviolet light\u2010induced inflammation and apoptosis in murine 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