{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:43Z","timestamp":1787014423579,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Famciclovir is a guanine analog antiviral drug used commonly for herpes zoster. Efficacy of famciclovir treatment has been reported to be comparable to valacyclovir treatment. Both of these medications reduce the time to complete cessation of zoster\u2010associated pain including post\u2010herpetic neuralgia, as compared to acyclovir. We conducted a multicenter, randomized, open clinical trial in order to evaluate the extent of pain relief afforded by these two antiviral drugs during the acute disease phase of herpes zoster. The study group comprised 86 immunocompetent adult patients suffering from herpes zoster, who were treated with either famciclovir or valacyclovir for 7\u2003days. Of these, 55 patients enrolled in this study within 72\u2003h of the onset of the rash and 31 patients after 72\u2003h of the onset. There was a significant reduction in acute herpes zoster pain with famciclovir on day 7 and at 2\u20133\u2003weeks in both of these patient groups, while with valacyclovir, there was not significant reduction in pain on day 7. Of patients aged 50\u2003years or older, there was a significantly earlier reduction in pain with famciclovir than with valacyclovir. In addition, a significant reduction in the number of patients with pain was observed as early as days 3\u20134 with famciclovir treatment as compared with valacyclovir treatment. We conclude that famciclovir was superior to valacyclovir in the relief of acute pain of herpes zoster. Accordingly, famciclovir is recommended for herpes zoster patients with moderate symptoms and a visual analog scale score of under 50\u2003mm.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01584.x","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T09:29:31Z","timestamp":1338542971000},"page":"902-908","source":"Crossref","is-referenced-by-count":20,"title":["Comparison between famciclovir and valacyclovir for acute pain in adult Japanese immunocompetent patients with herpes 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