{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:06:11Z","timestamp":1790179571596,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010helper (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h) cells, including <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 cells, may play an important role in the pathogenesis of psoriasis vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>). Acitretin is an effective treatment for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>; however, its influence on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h cells during the treatment of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> is unclear. This study aimed to investigate the influence of acitretin on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 cells in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients. <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) received acitretin p.o. (20\u00a0mg\/day) for 8\u00a0weeks. Sera and skin biopsies were obtained before and after treatment. Double\u2010labeled immunofluorescence was used to analyze <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> T<\/jats:styled-content>h1, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 cells in skin lesions. Enzyme\u2010linked immunosorbent assay and western blot were used to analyze the expressions of interferon (<jats:styled-content style=\"fixed-case\">IFN)<\/jats:styled-content>\u2010\u03b3, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in sera and skin lesions. The expressions of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20104 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in skin lesions were detected by <jats:italic>in situ<\/jats:italic> hybridization. Acitretin decreased the quantity of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> T<\/jats:styled-content>h1 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 cells in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> lesions, but had no significant influence on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 cells. Acitretin also decreased the expression of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in serum and lesions. The expressions of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> decreased significantly after 8\u00a0weeks of therapy. However, acitretin had no significant influence on the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 protein and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>. Acitretin can reverse <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 preponderance in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients to some degree. This may be due to the mechanism of acitretin on <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>; however, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 cells were not affected by acitretin treatment.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01637.x","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T06:35:30Z","timestamp":1345703730000},"page":"916-921","source":"Crossref","is-referenced-by-count":41,"title":["Acitretin exerted a greater influence on <scp>T<\/scp>\u2010helper (<scp>T<\/scp>h)1 and <scp>T<\/scp>h17 than on <scp>T<\/scp>h2 cells in treatment of psoriasis vulgaris"],"prefix":"10.1111","volume":"39","author":[{"given":"Xinwu","family":"NIU","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Medical College of Xi'an JiaoTong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"CAO","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baoji Central Hospital Baoji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqun","family":"MA","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Medical College of Xi'an JiaoTong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"FENG","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Medical College of Xi'an JiaoTong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"LI","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baoji Central Hospital Baoji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baoji Central Hospital Baoji China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.12.1537"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03321.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.11.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1038\/jid.1995.18","article-title":"Intralesional T\u2010lymphocyte activation as a mediator of psoriatic epidermal hyperplasia","volume":"105","author":"Bata\u2010Csorgo Z","year":"1995","journal-title":"J Invest 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