{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:10:36Z","timestamp":1788351036181,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paraneoplastic pemphigus (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) is a rare, life\u2010threatening, autoimmune, mucocutaneous blistering disease associated with neoplasia. Both humoral and cellular immunity are involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. Characteristically, <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> has a diverse spectrum of clinical and immunopathological features. We retrospectively analyzed 12 <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean patients with <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> who were diagnosed between 1993 and 2011. We performed analysis of the clinical features, clinical outcomes, underlying neoplasia, histological features and laboratory findings. All of the patients except one had severe mucosal involvement. Two patients had only mucosal lesions but no cutaneous involvement was observed. Erythema multiforme or lichen planus\u2010like eruptions rather than bullous lesions were more commonly observed skin rashes. The most common histological features were interface dermatitis and apoptotic keratinocytes. There were associated hematological\u2010related neoplasms in 11 patients, with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>astleman's disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) as the most frequent. Twelve patients were followed for 5\u2013148\u00a0months (mean, 43.0). The prognosis depended on the nature of the underlying neoplasm. Six patients died due to respiratory failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), postoperative septicemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and sarcomatosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). The 2\u2010year survival rate was 50.0%, and the median survival period after diagnosis was 21.0\u00a0months. Immunoblotting was performed in 12 patients and autoantibodies to plakins were detected in 11 patients. The results of this study demonstrated the clinical, histological and immunological diversity of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. Widely accepted diagnostic criteria that account for the diversity of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> are needed.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01655.x","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T08:31:54Z","timestamp":1346661114000},"page":"973-981","source":"Crossref","is-referenced-by-count":39,"title":["Retrospective analysis of 12 <scp>K<\/scp>orean patients with paraneoplastic pemphigus"],"prefix":"10.1111","volume":"39","author":[{"given":"Yuri","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Hwa","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonbuk National University Medical School 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