{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T14:22:36Z","timestamp":1750170156244},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dermatitis herpetiformis (<jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>) is common in some Caucasian populations but extremely rare in Japanese, probably because of different immunogenetic backgrounds. We report two Japanese <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> cases with typical clinical, histological and direct immunofluorescence features. However, no symptom of gluten\u2010sensitive enteropathy was shown. The diagnosis was confirmed by eliminating other autoimmune blistering diseases by indirect immunofluorescence, enzyme\u2010linked immunosorbent assays and immunoblotting. However, circulating immunoglobulin (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g)<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> anti\u2010endomysium, reticulin and gliadin antibodies were not detected. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibodies to tissue and epidermal transglutaminases were also negative. One case was associated with lung cancer and the other one with autoimmune pancreatitis. On review of 17 cases of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> reported in Japan over the previous 10\u00a0years, including our cases, one case was associated with gluten\u2010sensitive enteropathy, four with malignant neoplasms, two with autoimmune systemic disorders and one with psoriasis. Although our cases were typical of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> in clinical, histopathological and IgA deposit features, they showed different human leukocyte antigen haplotypes, no gluten\u2010sensitive enteropathy and no <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\u2010specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibodies, including those to epidermal and tissue transglutaminases. These results suggest that studies of unique characteristics in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> patients should facilitate further understanding of pathogenesis in <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01663.x","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T10:31:38Z","timestamp":1347359498000},"page":"1002-1005","source":"Crossref","is-referenced-by-count":4,"title":["Two <scp>J<\/scp>apanese cases of dermatitis herpetiformis associated each with lung cancer and autoimmune pancreatitis but showing no intestinal symptom or circulating immunoglobulin <scp>A<\/scp> antibodies to any known antigens"],"prefix":"10.1111","volume":"39","author":[{"given":"Mika","family":"Shigeta","sequence":"first","affiliation":[{"name":"Shigeta Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagano Municipal Hospital Nagano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Ohata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minao","family":"Furumura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Zone","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"Karpati","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology of the Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassian","family":"Sitaru","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Freiburg Medical Center Freiburg 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