{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:23:14Z","timestamp":1791116594808,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"\n ABSTRACT<\/jats:bold>\n <\/jats:title>\n \n Helicobacter pylori<\/jats:italic>\n was incriminated as an etiological factor of rosacea. However, there is still controversy about this association. We conducted a comparative study in order to assess the role of\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n in rosacea patients who had dyspeptic symptoms. The study included 68 patients and 54 controls. Screening for\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n was performed and positive cases were referred for gastric endoscopy. The inflammatory response and bacterial density were evaluated in gastric biopsy.\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n vacA<\/jats:italic>\n alleles,\n cagA<\/jats:italic>\n and\n iceA<\/jats:italic>\n genotypes were assessed by polymerase chain reaction. We found that 49 rosacea (72%) and 25 controls (46.3%) were infected with\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n . Thirty\u2010one rosacea cases were papulopustular (\n PPR<\/jats:styled-content>\n ) while 18 were erythematotelangiectatic (\n ETR<\/jats:styled-content>\n ). Gastric ulceration was higher in\n PPR<\/jats:styled-content>\n cases (38.7%) than\n ETR<\/jats:styled-content>\n (11.1%) and controls (12%). A significant inflammatory reaction was observed more in\n PPR<\/jats:styled-content>\n cases (74.2%) compared with 44.4% in\n ETR<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.04) and 44% in controls (\n P<\/jats:italic>\n \u00a0=\u00a00.02). Analysis of\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n genotypes revealed that\n vacA<\/jats:italic>\n s1m1 was more identified in\n PPR<\/jats:styled-content>\n cases (54.8%) compared with 22.2% in\n ETR<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.03) and 16% in controls (\n P<\/jats:italic>\n \u00a0=\u00a00.003). There was a significant elevation of\n cagA<\/jats:italic>\n \/<\/jats:italic>\n vacA<\/jats:italic>\n s1m1 positivity in\n PPR<\/jats:styled-content>\n cases. After the eradication regimen of\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n , a significant improvement (\n P<\/jats:italic>\n \u00a0<\u00a00.05) was observed in 15 out of 27\n PPR<\/jats:styled-content>\n cases (55.6%) compared with three out of 17\n ETR<\/jats:styled-content>\n (17.6%). We concluded that\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n has a significant role in rosacea patients who had dyspeptic symptoms. The PPR type is more influenced by\n \n H<\/jats:styled-content>\n .\u00a0pylori\n <\/jats:italic>\n and this is regarded as being because of certain virulent strains that increase the inflammatory response in gastric mucosa and also in cutaneous lesions.\n <\/jats:p>","DOI":"10.1111\/j.1346-8138.2012.01675.x","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T12:53:47Z","timestamp":1349441627000},"page":"989-995","source":"Crossref","is-referenced-by-count":26,"title":["Role of\n \n H<\/scp>\n elicobacter pylori\n <\/i>\n in common rosacea subtypes: A genotypic comparative study of\n E<\/scp>\n gyptian patients"],"prefix":"10.1111","volume":"39","author":[{"given":"Mohamed","family":"El\u2010khalawany","sequence":"first","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u2010Sadat","family":"Mosbeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Abd Alsalam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Ghonaim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany","family":"Abou\u2010bakr","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Institute Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"16","article-title":"Advances in understanding and managing rosacea: part 1: connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema","volume":"5","author":"Del Rosso JQ","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(11)70089-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(11)70088-6"},{"key":"e_1_2_6_5_1","first-page":"1603","article-title":"Helicobacter pylori in patients with rosacea","volume":"89","author":"Rebora A","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_6_1","first-page":"22","article-title":"Prevalence of Helicobacter pylori infection in patients with peptic disease","volume":"95","author":"Sirinthornpunya S","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.9.2597-2603.1998"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.642-674.1999"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.29.11.2543-2549.1991"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.030"},{"key":"e_1_2_6_14_1","first-page":"563","article-title":"Helicobacter pylori among Egyptian patients with chronic liver diseases. 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