{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:24:03Z","timestamp":1769646243368,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Epstein\u2010Barr virus associated hemophagocytic lymphohistiocytosis (EBV\u2010HLH) has a high mortality rate among children. The pathogenesis of, and underlying predisposing factors for, EBV\u2010HLH are as yet unclear; however, natural killer cells may play a key role in progression of the disease. This study attempted to determine whether killer cell immunoglobulin\u2010like receptor (KIR) gene polymorphisms are responsible for susceptibility to EBV\u2010HLH. Of the 125 children with EBV infection studied, 59 had EBV\u2010HLH and 66 patients had EBV associated infectious mononucleosis (IM) without HLH. The control group was 146 normal children without immune deficiency. KIR polymorphisms were determined by polymerase chain reaction with sequence\u2010specific primers. KIR polymorphism data were analyzed using the X<jats:sup>2<\/jats:sup> test or Fisher's exact test. The overall observed carrier frequency (OF) of KIR2DS5 was significantly higher in EBV\u2010HLH patients than in IM patients and normal controls (49.2% versus 31.8%, <jats:italic>P <\/jats:italic>= 0.048; 49.2% versus 31.5%, <jats:italic>P <\/jats:italic>= 0.018, respectively), and the odds ratios (95% confidence interval) were 2.071 (1.001\u20134.286) and 2.101(1.132\u20133.900) respectively. The OF of KIR3DS1 was significantly higher in the EBV\u2010HLH patients than in the IM patients (47.4% versus 24.6%, <jats:italic>P \u2003<\/jats:italic>=\u2003 0.012), but not different from normal controls. In summary, KIR polymorphisms may be involved in the development of EBV\u2010HLH, with KIR2DS5 promoting susceptibility to this disease. The obtained KIR data will enrich the understanding of genetic relationships among diseases associated with EBV infection in children.<\/jats:p>","DOI":"10.1111\/j.1348-0421.2012.00443.x","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T22:06:22Z","timestamp":1330553182000},"page":"378-384","source":"Crossref","is-referenced-by-count":10,"title":["Killer cell immunoglobulin\u2010like receptor gene polymorphisms predispose susceptibility to Epstein\u2010Barr virus associated hemophagocytic lymphohistiocytosis in Chinese children"],"prefix":"10.1111","volume":"56","author":[{"given":"Qin","family":"Qiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie","family":"Zhengde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Chunyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Zhizhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Junmei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Junhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Inge","family":"Henter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Kunling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1534"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/318796"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(02)00117-8"},{"key":"e_1_2_8_7_2","first-page":"181","article-title":"Prospective study of hemophagocytic lymphohistiocytosis","volume":"24","author":"Yang S.H.","year":"2009","journal-title":"J Appl Clin Pediatris"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10515"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009058510"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116721"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)80025-4"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.4049\/jimmunol.159.5.2075","article-title":"Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory\/activatory counterparts","volume":"159","author":"Vely F.","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1570"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-009-0378-7"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-27743-9_12"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03424.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902621"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i12.1770"},{"key":"e_1_2_8_19_2","article-title":"Screening the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK gene mutations in Chinese children with Epstein\u2013Barr virus\u2010associated hemophagocytic lymphohistiocytosis","author":"Zhizhuo H.","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01777-06"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012381"},{"key":"e_1_2_8_22_2","first-page":"538","article-title":"Genetic polymorphisms of killer cell immunoglobulin\u2010like receptors are associated with susceptibility to leptospirosis: a preliminary study","volume":"67","author":"Martins L.","year":"2006","journal-title":"Tissue Antigens"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.11.001"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182174a76"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020079"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02449-07"},{"key":"e_1_2_8_27_2","first-page":"1017","article-title":"Distinct KIR\/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses","volume":"118","author":"Ahlenstiel G.","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403525"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11730"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.2818"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01177.x"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1348-0421.2012.00443.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1348-0421.2012.00443.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:59:31Z","timestamp":1697471971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1348-0421.2012.00443.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1348-0421.2012.00443.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1348-0421.2012.00443.x","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}