{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:49:09Z","timestamp":1791103749451,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This work characterizes MLS<jats:sub>b<\/jats:sub> resistance in 39 methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) and 32 <jats:italic>Staphylococcus epidermidis<\/jats:italic> (MRSE) isolates. Of 21 <jats:italic>erm<\/jats:italic>(A) gene encoding MRSA isolates, 71.4% carried SCC<jats:italic>mec<\/jats:italic>III, whereas of 12 isolates carrying the <jats:italic>erm<\/jats:italic>(C) gene, 83.3% carried SCC<jats:italic>mec<\/jats:italic>IV. Among the 25 MRSE isolates positive for the <jats:italic>erm<\/jats:italic>(C) gene, 80% had SCC<jats:italic>mec<\/jats:italic>IV or nontypeable cassettes. Isolates carrying these genes had MIC<jats:sub>90<\/jats:sub>\u2265 256 \u03bcg\/mL to erythromycin and clindamycin. The <jats:italic>msr<\/jats:italic>(A) gene was associated with a low MIC<jats:sub>90<\/jats:sub> to these drugs. The <jats:italic>erm<\/jats:italic>(A) gene was associated with SCC<jats:italic>mec<\/jats:italic>III in MRSA isolates, whereas the <jats:italic>erm<\/jats:italic>(C) gene was associated with SCC<jats:italic>mec<\/jats:italic>IV in both MRSA and MRSE isolates.<\/jats:p>","DOI":"10.1111\/j.1348-0421.2012.00481.x","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T15:47:59Z","timestamp":1338997679000},"page":"647-650","source":"Crossref","is-referenced-by-count":16,"title":["Characterization of MLS<sub>b<\/sub> resistance among <i>Staphylococcus aureus<\/i> and <i>Staphylococcus epidermidis<\/i> isolates carrying different SCC<i>mec<\/i> types"],"prefix":"10.1111","volume":"56","author":[{"given":"Cristiane R. S.","family":"Teodoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio S.","family":"Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda S.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia R. N. dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(07)72175-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2200"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2182"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00724-08"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4240-4245.2004"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.489"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1062"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.04.007"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1686-1691.2006"},{"key":"e_1_2_5_11_2","unstructured":"CLSI \u2013 Clinical and Laboratory Standards Institute. (2010)Performance standards for antimicrobial susceptibility testing\u2013tenth edition supplement M02\u2010A10."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00165-06"},{"key":"e_1_2_5_13_2","first-page":"447","article-title":"A comparison of adult and pediatric methicillin\u2010resistant Staphylococcus aureus isolates collected from patients at a University Hospital in Korea","volume":"45","author":"Park J.Y.","year":"2007","journal-title":"J Microbiol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46962-0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04089.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.05.002"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-011-0017-1"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1413-8670(10)70113-6"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.11.014"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01174.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02582-05"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1990.tb00696.x"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1348-0421.2012.00481.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1348-0421.2012.00481.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:39:18Z","timestamp":1698658758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1348-0421.2012.00481.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,24]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1348-0421.2012.00481.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1348-0421.2012.00481.x","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,24]]}}}