{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:08Z","timestamp":1787014448598,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe pneumonia and leukocytosis are characteristic, frequently observed, clinical findings in pediatric patients with pandemic A\/H1N1\/2009 influenza virus infection. The aim of this study was to elucidate the role of cytokines and chemokines in complicating pneumonia and leukocytosis in patients with pandemic A\/H1N1\/2009 influenza virus infection. Forty\u2010seven patients with pandemic A\/H1N1\/2009 influenza virus infection were enrolled in this study. Expression of interleukin (IL)\u201010 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.027) and IL\u20105 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.014) was significantly greater in patients with pneumonia than in those without pneumonia. Additionally, serum concentrations of interferon\u2010\u03b3 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.009), tumor necrosis factor\u2010\u03b1 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.01), IL\u20104 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.024), and IL\u20102 (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.012) were significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without neutrophilic leukocytosis. Of the five serum chemokine concentrations assessed, only IL\u20108 was significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without leukocytosis (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.001). These cytokines and chemokines may play important roles in the pathogenesis of childhood pneumonia associated with A\/H1N1\/2009 influenza virus infection.\n                  <\/jats:p>","DOI":"10.1111\/j.1348-0421.2012.00489.x","type":"journal-article","created":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T20:58:21Z","timestamp":1340744301000},"page":"651-655","source":"Crossref","is-referenced-by-count":15,"title":["Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A\/H1N1\/2009 influenza virus"],"prefix":"10.1111","volume":"56","author":[{"given":"Yuji","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sugata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ihira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomochika","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904252"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091724"},{"key":"e_1_2_4_4_2","first-page":"1","article-title":"Influenza virus infection in Indian patients","volume":"5","author":"Arankalle V.A.","year":"2009","journal-title":"PloS one"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/650581"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08260"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177127"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/655469"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9259"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8208"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008393"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9324"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1041-9"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0115-z"},{"key":"e_1_2_4_15_2","first-page":"10","article-title":"Evaluation of reverse transcription loop\u2010mediated isothermal amplification assays for rapid diagnosis of pandemic influenza A\/H1N1 2009 virus","volume":"83","author":"Nakauchi M.","year":"2011","journal-title":"J MedVirol"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01090.x"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1348-0421.2012.00489.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1348-0421.2012.00489.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:39:21Z","timestamp":1698644361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1348-0421.2012.00489.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,24]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1348-0421.2012.00489.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1348-0421.2012.00489.x","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,24]]}}}